老年原发性高血压患者脉搏波传导速度与心脑血管危险因素关系的研究

The Correlation of Pulse Wave Velocity with Cardiovascular Risk Factors in Patients with Essential Hypertension

目的:探讨老年原发性高血压患者脉搏波传导速度与心脑血管危险因素关系。方法:随机选取2012年5月至2012年8月在我院体检的160例新诊老年原发性高血压患者及120例健康个体,所有个体均未接受治疗,采用动脉硬化检测仪测定患者肱踝脉搏波传导速度(baPWV),同时测量身高、腰围、体重、血压、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBS)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、肌酐(Cr)等指标,探讨老年原发性高血压患者高脂血症、吸烟、肥胖、糖尿病等危险因素与baPWV指标变化的关系。结果:不同血压分级的老年原发性高血压患者之间肱踝脉搏波传导速度值存在显著差异(P<0.01)。合并冠心病、肥胖、糖尿病、吸烟、高脂血症等危险因素的高血压患者baPWV值显著高于单纯性原发性高血压患者(P<0.01)。多元回归分析表明:吸烟史(P<0.01)、冠心病史(P<0.01)、糖尿病史(P<0.01)、年龄(P<0.01)、腰围(P<0.01)、血压(P<0.01)、HDL-C(P<0.01)、TC(P<0.01)、FBS(P<0.01)、LDL-C(P<0.01)、Cr(P<0.01)是baPWV升高的独立风险因素。结论:老年原发性高血压患者存在不同程度的的动脉僵硬增高,常见心脑血管风险因素同样影响老年原发性高血压患者僵硬度。

Objective： To investigate the association of pulse wave velocity and cardiovascular risk factors in elderly hypertensive patients. Methods： From May 2012 fo August 2012, 160 newly diagnosed elderly patients with essential hypertension were randomly selected from cardiology outpatient department. Brachial-ankle pulse wave velocity （baPWV） were measured by arteriosclerosis detection, simultaneous measurement of the height, waist circumference, body weight, blood pressure, total cholesterol （TC）, triglyceride （TG）, fasting blood sugar （FBS）, low-density lipoprotein cholesterol（LDL-C）, high density lipoprotein lipoprotein cholesterol （HDL-C）, uric acid （UA）, creatinine （Cr） and other indicators, to explore the relationship between changes with hyperlipidemia, smoking, obesity, diabetes and other risk factors associated with baPWV indicators in elderly hypertensive patients. Results： Brachial-ankle pulse wave velocity values were significantly different（P〈0.01） between the different classification of blood pressure in elderly patients with essential hypertension. Coronary heart disease, obesity, diabetes, smoking, hyperlipidemia and other risk factors in hypertensive patients with baPWV value was significantly higher than the Simple patients with essential hypertension（P〈0.01）. Multiple regression analysis showed that a history of smoking （P〈0.01）, history of coronary artery disease （P〈0.01）, history of diabetes （P〈0.01）, age （P〈0.01）, waist circumference （P〈0.01）, blood pressure （P〈0.01）, HDL-C （P〈0.01）, TC （P〈0.01）, FBS （P〈0.01）, LDL-C （P〈0.01）, Cr （P〈0.01） were independent risk factors of increase of baPWV. Conclusion： The elderly hypertensive patients had different degrees of increased arterial stiffness, common cardiovascular risk factors also affected the stiffness of elderly patients with essential hypertension.