三金排石汤对特发性钙结石患者24小时尿成石危险因素水平的影响

The Effect of Sanjin Paishi Tang s' Intervention on the Levels of 24-hour Urinary Stone Risk Factors in Patients with Idiopathic Calcium Stone

目的：分析三金排石汤对特发性钙结石患者24小时尿成石危险因素水平的影响,探讨其用于预防手术取石后的特发性钙结石患者结石复发的临床价值。方法：选择2009年9月-2013年9月入住我院的经皮肾镜取石术或输尿管镜取石术治疗的特发性钙结石患者100例,前瞻性将其随机分为治疗组和观察组,两组各50例。治疗组予三金排石汤每日一剂分两次煎服,观察组予正常饮食,测定和比较两组患者治疗前和治疗1个月后的24小时尿成石危险因素水平。结果：治疗1个月后,观察组24小时尿成石危险因素水平与治疗前比较差异均无统计学意义（P〉0.05）;治疗组24小时尿量较治疗前显著增加,尿pH值、尿枸橼酸含量明显升高,尿钙显著降低,差异均有统计学意义（P〈0.05）,但尿钠、尿镁、尿磷、尿尿酸及尿草酸水平与治疗前比较差异均无统计学意义（P〉0.05）;与观察组比较,治疗组24小时尿量明显增加,尿pH值、尿枸橼酸含量显著升高,尿钙水平明显降低,差异均有统计学意义（P〈0.05）,但两组尿钠、尿镁、尿磷、尿尿酸及尿草酸水平比较差异均无统计学意义（P〉0.05）。结论：三金排石汤治疗手术取石后特发性钙结石患者能够显著增加其24小时尿量及尿枸橼酸含量,并减少尿钙含量,抑制结石形成,这可能有助于降低特发性钙结石患者手术取石后的复发风险,值得临床研究和推广。

Objective： To Analyze the effect of Sanjin Paishi Tang on the levels of 24-hour Urinary Stone Risk Factors in patients with idiopathic calcium stone, and explore the clinical value of it on the prevention of recurrence of patients with idiopathic calcium stone underwent calculus removed surgery. Methods： 100 cases of patients with idiopathic calcium stone were selected in our hospital from September 2009 to September 2013, and were randomly divided into the treatment group（n=50） and observation group（n=50）. The treatment group was treated by Sanjin paishi Tang twice a day, while the observation group had normal diet. The levels of 24-hour urinary stone risk factors before and one month after the treatment were measured and compared between the two groups. Results： After1 month＇treatment, the levels of 24-hour urinary stone risk factors of observation group had no statistical difference compared with those before treatment（P〈0.05）. The urine output, pH of urine and urinary citrate of treatment group were all increased significantly and urinary calcium was obviously decreased（P〈0.05）. but no significant difference was found in the levels of ingredients in urine such as sodium,magnesium, phosphorus, uric acid and urinary oxalate（P〈0.05）. Compared with the observation group, the urine output, pH of urine and urinary citrate of the treatment group increased significantly and urinary calcium decreased（P〈0.05）, but no significant difference was found in the levels of ingredients in urine such as sodium, magnesium, phosphorus, uric acid and urinary oxalate between the observation group and the treatment group（P〈0.05）. Conclusion： Sanjin Paishi Tang could effectively increase the the urine output and urinary cirtrate, decrease the excretion of urinary calcium and inhibit lithogenesis in the treatment of patients with idiopathic calcium stone underwent calculus removed surgery, which may be useful to decrease the risk of recurrence of patients with idiopathic calcium stone underwent calculus removed surgery.