纳米载药系统在肿瘤多药耐药中的应用

The Application of Nanoparticles Drug System in Cancer Multidrug Resistance

当今世界,肿瘤已经成为威胁人类健康的重大疾病。在肿瘤疾病中,化疗可控制肿瘤的生长和转移,增强放疗的疗效,是治疗肿瘤疾病的主要手段之一。而肿瘤多药耐药是影响化疗药物疗效、引起化疗失败的重要原因,影响肿瘤患者的治愈效果,降低生存率。如何提高化疗的疗效,延长肿瘤患者的寿命成为医学界的难题。纳米载药系统是生物医学领域研究的热点,相对于单一药物,纳米载药体现了许多优越性,具有良好的应用前景。纳米级颗粒更有利于药代动力学,这些纳米载药颗粒通过被动和主动的机制表现出在全身血液循环寿命延长,持续的药物释放动力,使其能更好的在肿瘤细胞中积累而发挥作用,提高化疗的疗效。本文综述了肿瘤多药耐药研究中主要的纳米载体以及它们在逆转多药耐药方面的应用,并展望载药系统的有更多更好的发展趋势。

At present, cancer is a serious diease that is threatening the health of human. Chemotherapy has been one of the most treatment method for cancer that can control the growth and transference for cancer, enhance the efficacy of radiotherapy. Cancer multidrug resistance is the important element that influences treatment efficacy for cancer, and is the most important failture reason for treating cancer, influences the efficacy of treating and decreases the survive rate. How to elevate the efficacy of chemotherapy and postpone the life of patient is the challenge for medicine. Nano particle is better beneficial for the pharmacokinetics, those nano particle prolongs lifetime in the blood circulation by active and passive mechanism, extends dynamic of drug release consistently, it can be better for accumulating and developing function, so that it can highlight the efficacy of drug. The nanoparticles drug system is the hot topic in bimedicine, it has much more advantages than single drug. There is a super prospective in medical application. We clarify the major nanocarriers and their applications in multidrug resistance, and the uses in the field of reversion nanoparticle drug, hope that the future developing trend.