AEBP1在结直肠癌中的表达及其意义

Expression of AEBP1 in Colorectal Adenocarcinoma and its Clinical Significance

目的:研究脂肪细胞增强结合蛋白1(AEBP1)在结直肠癌组织中的表达情况,以探索其临床意义。方法:运用免疫组织化学和实时定量PCR技术,对AEBP1在结直肠癌中的表达情况进行检测,并分析其表达量与患者临床病理特征的关系。结果:AEBP1在结直肠正常组织、腺瘤和癌组织中的免疫评分有明显差异(P<0.05),而且AEBP1的阳性表达与肿瘤的分期和浸润深度明显相关。基因水平AEBP1的表达在肿瘤组织中明显高于正常组织。结论:AEBP1在结直肠癌组织中存在异常表达,并且可能是结直肠癌早期诊断和浸润深度的肿瘤标志物。

Objective： To investigate the association between the expression of Adipocyte enhancer-binding protein 1 （AEBP1） and the clinicopathological characteristics of CRC patients in order to t＇md out the clinical significance of this protein. Methods： The AEBP1 expression levels were determined by immunohistochemistry and qPCR. The relationship of the expression of AEBP1 and clinicopathological characteristics was analyzed. Results： There were significant difference of the AEBP1 expression in CRC tissues and Adenoma tissues compared with Normal tissues （P〈0.05）; the expression of AEBP1 was correlated with TNM staging and tumor invasion. Moreover, AEBP1 mRNA expression levels were also significantly different between CRC tissues and their corresponding normal tissues. Conclusion： Our results indicate that AEBP1 protein expression is aberrantly detected in CRC tissues, and has potential value ofbiomarker for CRC early detection and tumor invasion.