维生素D调节支气管哮喘气道平滑肌的研究进展

The effects of Vitamin D on airway smooth muscle in bronchial asthma

气道平滑肌的过度增生、肥大及功能异常，可能是支气管哮喘（简称哮喘）的发病机制之一。新近研究发现，除了对骨骼和钙代谢有明确的作用，维生素D还可调节气道平滑肌的增殖、收缩，并在哮喘的免疫调节方面起着重要的调控作用，从而影响气道炎症、气道重塑等哮喘的病理生理过程。本文就维生素D调节哮喘气道平滑肌的研究进展作一综述。

Excessive hyperplasia, hypertrophy and dysfunction of airway smooth muscle may be one of the pathogenesis of bronchial asthma （asthma）. In addition to the distinct role of Vitamin D in bone and calcium metabolism, Vitamin D may regulate the proliferation and contraction of airway smooth muscle. Besides, Vitamin D plays a pivotal role in immunoregulation of asthma. Those may influence the pathophysiological process of asthma,including airway inflammation, airway remodeling and so on. This review summarizes the effects of Vitamin D on airway smooth muscle in asthma.