摘要
目的比较高血压伴心力衰竭患者和单纯高血压患者血浆Apelin水平的差异。方法选取130例原发性高血压患者,根据是否有心力衰竭分为高血压伴心力衰竭组86例和单纯高血压组44例,检测2组患者血浆Apelin水平及脑钠肽(BNP)含量,同时测量左室射血分数(LVEF)、左心室舒张期内径(LVDD)以及左室后壁厚度(LVPW)并进行比较。结果与单纯高血压患者相比,高血压伴心力衰竭患者血浆Apelin水平显著降低(P<0.05)。年龄增加、BNP水平升高、血浆Apelin水平降低、左室肥厚等与高血压发展为心力衰竭呈正相关(P<0.05或P<0.01)。结论在确定高血压伴心力衰竭患者危险分级时血浆Apelin水平可以作为一个观察指标。
Objective To compare the difference of plasma Apelin level between hypertensive patients with heart failure and simple hypertensive patients. Methods 130 patients with essential hypertensive were selected and divided into two groups, 86 hypertensive patients with heart-failure and 44 simple hypertensive patients.The plasma Apelin levels, brain natriuretic peptide （BNP） levels, left ventricular ejection fraction （LVEF）, left ventricular diastolic diameter （LVDD） and left ventricular wall （LVPW）were detected and compared. Results The plasma Apelin level in hypertensive patients with heart failure was decreased significantly than that in simple hypertensive patients （P〈0. 05 ）. Increased age, plasma level of BNP, left ventricular hypertrophy and decreased plasma level of Apelin were positively correlated with heart-failure in hypertensive patients （ P〈0. 05 or P〈0.01 ）. Conclusions In determining the danger classification of hypertensive patients with heart-failure ,plasma Apelin levels can be used as one of the outcome parameters.
出处
《实用老年医学》
CAS
2014年第8期652-654,共3页
Practical Geriatrics
基金
东莞市科研局立项课题(201310515000380)
