噻托溴铵治疗老年慢性阻塞性肺疾病稳定期患者的临床观察

Clinical observation of tiotropium bromide powder in the treatment for stable chronic obstructive pulmonary disease in the elderly patients

目的探讨噻托溴铵治疗老年慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效。方法 90例老年COPD稳定期患者均吸入噻托溴铵每日1粒,疗程3月,比较患者治疗前后肺功能、血气分析指标、慢性阻塞性肺疾病评估测试(CAT)评分。结果噻托溴铵治疗后血氧分压显著改善(P<0.05),二氧化碳分压明显降低(P<0.05);治疗前后CAT评分差异有统计学意义(P<0.05)。结论噻托溴铵吸入治疗老年COPD稳定期患者,能明显改善肺功能、改善氧合,缓解症状,提高生活质量,是治疗老年COPD稳定期患者的有效选择。

Objective To observe the clinical efficacy of tiotropium bromide in the treatment for stable chronic obstructive pulmonary disease （COPD） in the elderly patients. Methods Ninety elderly patients with stable COPD who inhaled tiotropium 1 capsule every day for 3 months were enrolled in this study. The pulmonary function, blood gas analysis, COPD assessment test （CAT） score were determined and compared before and after treatment. Results After treatment, PO2was significantly increased and PCO2 was significantly decreased （P〈0. 05）, CAT score was also significantly decreased（P〈0. 05）. Conclusions Tiotropium can significantly improve the lung function and oxygenation, alleviating the symptoms, enhancing the quality of life of the elderly patients with stable COPD.