贝那普利联合阿托伐他汀对老年高血压患者血管内皮舒张功能及高敏C反应蛋白、胰岛素水平改善的研究

Effect of benazepril combined with atorvastatin on endothelial diastolic function,high-sensitivity c-reactive protein and insulin levels in elderly patients with hypertension

目的观察贝那普利联合阿托伐他汀对老年高血压的降压作用及对高敏C反应蛋白、血管内皮舒张功能和胰岛素抵抗的改善作用。方法选择1-2级老年高血压患者84例,随机分为贝那普利组和贝那普利阿托伐他汀联合组,分别治疗12周,每周测血压2次,观察2组患者治疗前后血压、血脂、胰岛素敏感性的变化,以及高敏C反应蛋白、血管内皮依赖性舒张功能的变化。结果治疗12周后,除联合组显示降脂外,2组在降低血压、改善胰岛素抵抗、降低高敏C反应蛋白、改善内皮依赖性血管舒张功能方面,治疗后较治疗前差异均有统计学意义（P〈0.01）,但联合组治疗后较贝那普利组治疗后改善更显著（P〈0.01）。结论贝那普利和阿托伐他汀联合应用能有效降低1~2级老年高血压患者的血压,降低高敏C反应蛋白水平、改善胰岛素抵抗和内皮依赖性血管舒张功能。

Objective To observe the effect of bcnazepril combined with atorvastatin on blood pressure, high sensitive C reactive protein （ hs-CRP）, vascular endothelial function, insulin resistance in elderly patients with hypertension. Methods Eighty-four elderly patients with 1-2 grade essential hypertension were randomly divided into two group, benaze- pril group and benazepril combined atorvastatin group. Two groups were treated for 12 weeks, blood pressure was measured 2 times a week, the blood pressure, blood lipid, insulin sensitivity, hs-CRP and vascular endothelial dependent diastolic function of two groups were observed and analyzed before and after the treatment. Results The blood pressure, insulin resistance, hs-CRP, vascular endothelial function were all improved significantly in two groups after 12 weeks treatment （P〈0.01 ）.There was also significant difference between the two groups after treatment （P〈0. 01 ）. Conclusions The combined application of benazepril and atorvastatin statins can decrease the blood pressure and hs-CRP, improve insulin resistance and endothelial dependent vasodilation in elderly patients with 1-2 grade essential hypertension.