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低温在阿尔茨海默病发病中作用的研究现状 被引量：2

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摘要 老年人处于低温环境中和体温调节功能障碍时可引起原发性低温,但在临床上有许多病理性原因也能引起继发性低温,或者低温能引起和促进某些疾病的发生[1-4]。动物实验和临床研究证明,低体温能导致Tau蛋白过度磷酸化,引起和促进阿尔茨海默病（Alzheimer＇s disease,AD）的发生[1]。本文简要讨论不同原因引起的低温在AD发病中的作用及其机制的研究进展。
作者 杨永录 卜舒
机构地区 成都医学院体温与炎症四川省高校重点实验室
出处 《实用老年医学》 CAS 2014年第8期681-684,共4页 Practical Geriatrics
基金 四川省教育厅科研基金资助项目(12ZB204) 成都医学院学科建设项目专项经费资助(CYXK2012003)
关键词 低温环境 阿尔茨海默病 发病 体温调节功能障碍 临床研究 病理性原因 过度磷酸化 TAU蛋白
分类号 R749.16 [医药卫生—神经病学与精神病学]
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实用老年医学
2014年 第8期

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