摘要
目的 系统评价胰十二指肠切除术中,胰管支撑外引流与非引流术后胰瘘的发病率、总的并发症发病率、病死率以及住院天数.方法 检索Cochrane Library、PubMed、Embase、中国生物医学数据库等,查找关于胰十二指肠切除术中,胰管支撑外引流与非引流的随机对照试验,采用RevMan5.2软件进行Meta分析.结果 纳入4个随机对照试验,总共416例患者,术中行胰管支撑外引流的患者207例,未行胰管支撑引流的患者209例.Meta分析结果显示:胰十二指肠切除术中行胰管支撑外引流与未行胰管支撑引流相比,行胰管支撑外引流能够显著降低胰十二指肠切除术后胰瘘的发病率[RR =0.57,95% CI(0.41,0.80),P=0.001],尤其是胰管直径≤3.0 mm者的术后胰瘘的发病率[RR =0.55,95% CI(0.37,0.82),P=0.003]和质地较软胰腺者的术后胰瘘的发病率[RR =0.67,95% CI(0.45,0.99),P=0.040],降低术后并发症的发病率[RR =0.79,95% CI(0.64,0.98),P=0.030],缩短住院天数[WMD=-3.98,95% CI(-6.42,-1.54),P=0.001];两组在胰管直径>3.0 mm者的术后胰瘘的发病率[RR =0.37,95% CI(0.08,1.83),P=0.220],以及总的术后病死率[RR =0.86,95% CI(0.28,2.65),P=0.800]上差异无统计学意义.结论 胰十二指肠切除术中,行胰管支撑外引流能减少术后胰瘘的发病率,降低术后并发症的发生,缩短住院天数,值得在临床上推广应用.
Objective To systematically evaluate the postoperative pancreatic fistula rate,overall postoperative morbidity rate,overall postoperative mortality rate and length of stay in external stent group versus no stent group for pancreaticcoduodenectomy.Methods The Cochrane Library,PubMed,Embase and CBM data bases were searched to identify randomized controlled trials that compared the effectiveness of external stent versus no stent for pancreaticcoduodenectany.Meta-analysis was performed using the software RevMan 5.2.Results Four trials with 416 patients comparing external stent with no stent were included,the external stent group with 207 patients and the no stent group with 209 patients.The Meta-analysis revealed that,compared the external stent group with the no stent group,the rate of postoperative pancreatic fistula was significantly reduced in the external stent group [RR =0.57,95% CI(0.41,0.80),P =0.001],especially for the patinets of pancreatic diameter ≤ 3.0 mm[RR =0.55,95 % CI(0.37,0.82),P =0.003] and soft pancreatic [RR =0.67,95 % CI(0.45,0.99),P =0.040],the overall postoperative morbidity rate of external stent group versus.no stent group was reduced[RR =0.79,95 % CI (0.64,0.98),P =0.030],and length of stay was shortened [WMD =-3.98,95% CI(-6.42,-1.54),P =0.001].There was no difference between the two groups regarding the postoperative pancreatic fistula rate of diameter 〉 3.0 mm [RR =0.37,95 % CI(0.08,1.83),P =0.220],and the overall postoperative mortality rate [RR =0.86,95 % CI(0.28,2.65),P =0.800].Conclusions Exental stent significantly reduced the postoperative pancreatic fistula rate and overall postoperative morbidity rate 、shortened the length of stay,and thus it can be identified as a preferable option for Pancreaticcoduodenectomy.
出处
《国际外科学杂志》
2014年第9期597-603,F0003,共8页
International Journal of Surgery