Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu

AIM: To investigate the chemical constituents of the cultures of Laetiporus sulphureus(Bull.) Murrill. METHOD: Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported. RESULTS: Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one(2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(3) were isolated. CONCLUSION: Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L-1, respectively.

AIM： To investigate the chemical constituents of the cultures ofLaetiporus sulphureus （Bull.） Murrill. METHOD： Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported. RESULTS： Three mycophenolic acid derivatives, 6-（（2E, 6E）-3, 7-dimethyldeca-2, 6-dienyl）-7-hydroxy-5-methoxy-4-methylphtanlan-1-one （1）, 6-（（2E, 6E）-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl）-5, 7-dihydroxy-4-methylphtanlan-1-one （2）, and 6-（（2E, 6E）-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl）-7-hydroxy-5-methoxy-4-methylphtanlan-1-one （3） were isolated. CONCLUSION： Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with ICs0 values of 39.1, 31.1, 27.4, and 35.7μmol.L-1, respectively.