舒芬太尼预防罗库溴铵诱发肢体退缩反应合适给药时间观察被引量：2

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摘要目的探讨舒芬太尼抑制罗库溴铵注射痛引起的肢体退缩反应合适给药时间。方法择期全身麻醉患者59例,按性别分为男性组30例,女性组29例。丙泊酚靶控输注2.5μg·mL-1镇静,舒芬太尼0.5μg·kg-1静脉滴注,根据序贯法测定罗库溴铵给药时间,初始时间设定为120 s,间隔时间10 s。达预定时间后给予罗库溴铵0.6 mg·kg-1静脉注射。结果舒芬太尼抑制50%的男、女患者肢体退缩反应所需时间分别为39.4和48.0 s,95%的男女患者肢体退缩反应抑制所需时间分别51.2和64.5 s,男性组舒芬太尼所需要时间显著短于女性组(P<0.01)。结论通过调整给药时间,舒芬太尼能够抑制罗库溴铵诱发肢体退缩反应,且抑制退缩反应所需要时间女性长于男性。

作者陈玲阳林仙菊吴美燕王明仓

机构地区浙江省台州医院麻醉科浙江省台州恩泽妇产医院

出处《医药导报》 CAS 北大核心 2014年第9期1182-1184,共3页 Herald of Medicine

关键词舒芬太尼罗库溴铵注射痛序贯法给药时间

分类号 R971.2 [医药卫生—药品] R969.3 [医药卫生—药理学]

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1BORGEAT A,KWIATKOWSKI D. Spontaneous movementsassociated with rocuronium:is pain on injection the cause[J]. Br J Anaesth,1997,79(3):382-383.
2LUI J T,HUANG S J,YANG C Y,et al. Rocuronium-induced generalized spontaneous movements causepulmonary aspiration[J]. Chang Gung Med J,2002,25(9):617-620.
3MUKAT S,HIMANSHU C,GIRUNA C,et al. Effect of nar-cotic pretreatment on pain after rocuronium injection: arandomized, double-blind controlled comparison withlidocaine[J]. J Anesth,2007,21(4):510-512.
4PARK S J,PARK H J,CHOI J Y,et al. The influence ofage and gender on remifentanil EC50 for preventingrocuronium induced withdrawal movements[J]. Korean JAnesthesiol,2010,58(3):244-248.
5BAEK S H,WOO C M,LEE H J,et al. Rocuronium-indu-ced withdrawal movements associated with differentrocuronium injection method[J]. Paediatr Anaesth,2008,18(6):515-519.
6TUNCALI B,KARCI A,TUNCALI B E,et al. Dilution ofrocuronium to 0. 5 mg·mL-1 with 0. 9% NaCl eliminatesthe pain during intravenous injection in awake patiens[J].Anesth Analg,2004,99(3):740-743.
7HYUN J K,JI K,YONG B K,et al. Pharmacological pre-vention of rocuronium-induced injection pain or withdrawalmovements:a meta-analysis[J]. J Anesth,2013,27(5):742-749.
8AHMAD N,CHOY C Y,ARIS E A,et al. Preventing thewithdrawal response associated with rocuronium injection:acomparison of fentanyl with lidocaine[J]. Anesth Analg,2005,100(4):987-990.
9林仙菊,陈玲阳,项海飞.舒芬太尼预防罗库溴铵诱发肢体退缩反应EC_(50)测定[J].中国临床药理学与治疗学,2011,16(9):1052-1056. 被引量：5
10YOON J Y,KIM H K,KWON J Y,et al. EC50 of remi-fentanil to prevent withdrawal movement associated withinjection of rocuronium[J]. J Anesth,2010,24(2):182-186.

二级参考文献11

1Singh M, Chauhan C, Rath GP, et al. Effect of narcotic pretreatment on pain after rocuronium in- jection: a randomized, double-blind controlled com- parison with lidocaine[J].J Anesth, 2007, 21(4): 510-512.
2Borgeat A, Kwiatowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause[J].? BrJ Anaesth, 1997, -79(3) 382-383.
3Memis D, Turan A, Karamanliogy B, et aI. The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol and fentanyl[J].Anesth Analg, 2002, 94(6) 1517-1520.
4Back SH, Woo CM, Lee HJ, et al. Rocuronium-in- duced withdrawal movements associated with dif- ferent Rocuronium injection method [J]. Paediatr Anaesth,2008,18(6) :515-519.
5Tuncali B, Karci A, Tuncali BE, et al. Dilution of rocuronium to 0. 5mg/ml with 0. 9% NaCL eliminates the pain during intravenous injection in awake patiens[J]. Anesth Analg,2004,99(3) :740-743.
6Kim JY, Kwak HJ, Park KS, et al. Prevention of rocuronium-induced withdrawal movement in children: a comparison of remifentanil with alfentanil [J]. Paediatr Anaesth, 2008,18 ( 3 ) : 245 - 250.
7Ahmad N, Choy CY, Aris EA, et al. Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaine [J]. Anesth Analg, 2005,100(4) :987-990.
8Yoon JY, Kim HK, Kwon JY, et al. ECs0 of remifentanil to prevent withdrawal movement asso- ciated with injection oi rocuronium[J]. J Anesth, 2010, 24(2) :182-186.
9Kim KS, Kim YS, Jeon WJ, et al. Prevention of withdrawal associated with the injection of rocuroni- um in adults and children[J]. J Clin Anesth, 2006, 18(5) :334-338.
10Taylor IN, Keenny GN. Requirements for targetcontrolled infusion of propofol to insert the larynge- al mask airy[J]. Anaesthesia, 1998,53 (2) 222 - 226.