探讨生长抑素联合垂体后叶素在肝硬化失代偿大出血治疗中的作用

Somatostatin combine pituitrin in decompensated cirrhosis has a role inthe treatment of massive hemorrhage

目的探讨生长抑素（思他宁）联合用生理盐水稀释后的垂体后叶素在肝硬化失代偿消化道大出血治疗中的作用.方法：选入住我院消化内科的肝硬化失代偿消化道大出血病人,入院后随机分组,各为40 人,A 组患者给予生长抑素0.25mg/h 持续泵入,B 组患者生长抑素持续泵入联合用生理盐水稀释后的垂体后叶素持续泵入,其他治疗相同（如禁食、PPI 制剂、其它止血药及必要时的紧急输血治疗等）.结果：B 组患者在治疗后三天内患者再呕血次数少于A 组,出血停止的时间提前于A 组,紧急输血次数少于A 组,且B 治疗组患者病死率少于A 组,统计学有显著性差异.结论：肝硬化失代偿期消化道大出血患者治疗开始就及时的联合给予垂体后叶素泵入对减少患者再出血,提前止血及减少紧急输血次数,降低一定数量的死亡病人是有很大作用的.

ObjectiveTo investigate the somatostatin combined pituitrin in decompensated cirrhosis has a role in the treatment of digestive tract hemorrhage.Methods：Selectedin our hospital in patients with decompensated cirrhosis digestive tract hemorrhage of digestive internal medicine,after randomization,A group of patients given somatostatin 0.25 mg/hcontinuous pumping, somatostatin group B continue to pump into the joint pituitrin continuous pumping, other treatment of the same （e.g., fasting, PPI preparations, other hemostaticand blood transfusion treatment, etc.）.Results：Group B patients in the treatment of patients with hematemesis again within three days after the number less than group A,bleeding stoptime in advance in group A,blood transfusion number less than group A, B case fatality rate in treatment group patients less than group A,and has significant difference.Conclusion：Inpatients with decompensated cirrhosis of digestive hemorrhage treatment process begins in a timely manner of pituitrin pump into to reduce patients＇ bleeding again,stop bleeding andreduce the number of blood transfusion,in advance to reduce a certain number of death of patients there is a big role.