输注去白细胞红细胞对治疗急性白血病患者的影响

目的观察长期反复输血者一急性白血病患者输注去白细胞红细胞悬液与普通红细胞悬液的治疗效果、引起的非溶血性发热性输血反应NHFTR）和细胞免疫功能的比较,探讨二者的关联.方法：观察组选择我院50 例急性白血病患者用去白细胞红细胞悬液与对照组50 例白血病患者用普通红细胞悬液输注比较,两组化疗方案基本相同.结果：急性白血病患者输注去白细胞红细胞与普通红细胞悬液相比,溶血性发热性输血反应明显减少,患者的细胞免疫功能在治疗前无明显差异,治疗后观察组患者的细胞免疫功能（T3、T4、T4/T8、NK 细胞活性）均明显高于对照组（P〈0.05）.结论：急性白血病患者输血时, 应选择去白细胞红细胞悬液输注,可以预防NHFTR 和改善机体细胞免疫功能,其NHFTR 的降低可能与T3、T4、T4/T8、NK 细胞活性升高有关.

ObjectiveTo investigate the long and reduplicate-acute leukemia patients de- leukocyte transfusion and common transfusion ,comparison the therapy -inducedfebrile non -hemolytic transfusion reaction （NHFTR） and cellular immune function.Study related to the two .Methods：Observation 50 cases of acute leukemia in hospital patientswith de-leucocyte transfusion and control group 50 AL patients compared with common transfusion. The chemotherapy regimen of two groups were basically identical. Results：Theobvious decreased NHFTR with de-leucocyte transfusion compare to the group of common transfusion. There isn’t obvious disparity in the cellular immune function of two groupsbefore treatment, the cellular immune function of observation group（T3、T4、T4/T8、activity of NK cell） is obviously higher than control group after treatment （P〈0.05）.Conclusions：AL patients should choose de-leucocyte transfusion, with can prevent NHFTR and improve the cellular immune function. The decreased NHFTR mechanism may berelated to increased activity of T3、T4、T4/T8、NK cell.