皮肤树突状细胞亚群研究进展

Advances in skin dendritic cell subsets Research

皮肤树突状细胞（DC）作为重要的抗原提呈细胞,在机体免疫应答或自身耐受的发生中扮演着非常重要的角色.皮肤免疫系统中定居着多种DC亚群,主要包括表皮层中的郎格汉斯细胞（LC）与真皮层中的各种真皮DC亚群.健康皮肤中的DC亚群主要有表皮LC、真皮DC（dDC）和浆细胞DC（pDC）,dDC又分为Langerin＋ dDC及Langerin-dDC等.但在炎症性皮肤,如过敏性皮炎、银屑病等病变皮肤中则存在着炎症性DC亚群.DC由于其复杂的异质性群体,导致了其各亚群的特殊化功能.皮肤DC亚群的特殊化功能,为皮肤性疾病的临床治疗及新型疫苗的研发设计等都提供了良好的新策略.

Skin-derived dendritic cell （DC） are potent antigen-presenting cells with critical roles in both adaptive immunity and tolerance to self. The immune system of the skin has a network of resident DC con- sisting of epidermal Langerhans cells （LC） and various subsets of dermal DC. I）C subsets of healthy skin mainly include the epidermal LC, dermal dendritic cell（ dDC）, and plasmacytoid dendritic cell（pDC）, dDCs are divid- ed into Langerin ~ dDC and Langerin-dDC. In inflammatory skin, such as lesions in the skin of atopic dermatitis and psoriasis,there are inflammatory DC subsets. Because of the heterogeneous features of DC, each subset of DC has specialized functions. Skin DC subsets with specialized features provide new strategies for the treatment of skin diseases and the development of new vaccines.