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B细胞在移植免疫中的调节作用

The regulatory role of B cells in transplantation immunity
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摘要 传统认为,在移植免疫中B细胞作为抗原提呈细胞可加重T淋巴细胞介导的同种异体反应.但近期研究发现,某些B细胞亚群,如调节性B细胞（Bregs）具有免疫耐受性,在移植排斥反应中发挥负向调控作用,进而延缓同种异体移植排斥进程.因而研究B细胞在移植免疫中的调节作用,阐述B细胞发挥负向免疫调节机制及以B细胞为靶细胞的诱导移植耐受新策略具有重大意义. As antigen-presenting, B cells can aggravate T lymphocyte-mediated allograft reactions in transplantation immunity. However, recent studies have found that some B cell subsets, such as regulatory B cells （ Bregs）, have the character of immune tolerance and play a negative regulatory role in transplant rejection. Thus B cells delay the process of allograft rejection. This review will focus on the regulation of B lymphocyte in trans- plantation immunity,elaborate the negative immunoregulatory mechanisms of B cells and new immunotherapeutie strategies of induee transplantation tolerance with B cells as target cells.
作者 秦瑶 张梅
机构地区 南京医科大学第一附属医院内分泌科
出处 《国际免疫学杂志》 CAS 2014年第5期386-389,共4页 International Journal of Immunology
基金 国家自然科学基金（81070622 81370939） 江苏省六大人才高峰项目（2010-022）
关键词 B细胞 调节性B细胞 移植耐受 免疫治疗 B cells regulatory B cells Transplantation tolerance Immunotherapy
分类号 R392 [医药卫生—免疫学]
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参考文献32

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国际免疫学杂志
2014年 第5期

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