摘要
传统认为,在移植免疫中B细胞作为抗原提呈细胞可加重T淋巴细胞介导的同种异体反应.但近期研究发现,某些B细胞亚群,如调节性B细胞(Bregs)具有免疫耐受性,在移植排斥反应中发挥负向调控作用,进而延缓同种异体移植排斥进程.因而研究B细胞在移植免疫中的调节作用,阐述B细胞发挥负向免疫调节机制及以B细胞为靶细胞的诱导移植耐受新策略具有重大意义.
As antigen-presenting, B cells can aggravate T lymphocyte-mediated allograft reactions in transplantation immunity. However, recent studies have found that some B cell subsets, such as regulatory B cells ( Bregs), have the character of immune tolerance and play a negative regulatory role in transplant rejection. Thus B cells delay the process of allograft rejection. This review will focus on the regulation of B lymphocyte in trans- plantation immunity,elaborate the negative immunoregulatory mechanisms of B cells and new immunotherapeutie strategies of induee transplantation tolerance with B cells as target cells.
出处
《国际免疫学杂志》
CAS
2014年第5期386-389,共4页
International Journal of Immunology
基金
国家自然科学基金(81070622
81370939)
江苏省六大人才高峰项目(2010-022)
关键词
B细胞
调节性B细胞
移植耐受
免疫治疗
B cells
regulatory B cells
Transplantation tolerance
Immunotherapy