一氧化碳中毒引发迟发性脑病机制的研究进展

Progress in the research on the pathogenesis of delayed encephalopathy after carbon monoxide poisoning

机体在短时间内吸入了高浓度的一氧化碳毒性气体即可导致急性一氧化碳中毒,它是冬季较为常见的中毒性疾病之一,尤其在我国的北方地区发病率较高.此病在临床上的致残致死率极高,是急诊科常见的急危重症.患者多在经历一定时间的“假愈期”后发生一氧化碳中毒迟发性脑病,并且无法完全治愈,从而给社会和家庭造成严重的经济负担.但直到现在,一氧化碳中毒迟发性脑病的具体发病机制仍未完全阐明,并存在着多种学说.在此对一氧化碳中毒迟发性脑病发病机制的研究进行探讨,以期为其临床治疗提供新的思路及理论基础.

The inhalation of high concentration of carbon monoxide within short period of time might cause acute carbon monoxide poisoning, which is common in emergency ward in winter, especially in north China. The rate of disability and mortality caused by acute carbon monoxide poisoning remains high. Delayed encephalopathy could happen after a period of ＂latent phase＂ , which, however, can hardly be cured. This can also be serious economic burden to society and families. Till now, the exact pathogenesis of delayed encepha- lopathy after carbon monoxide poisoning remains to be illustrated. There are a variety of hypothesis for this dis- ease. In this review, we discuss the research progress about the pathogenesis of this disorder in order to provide new ideas for its clinical treatment.