我县318例药物不良反应汇总分析

Summarized analysis of 318 cases of adverse drug reactions in Shanxian county

目的分析本县近2年药物不良反应(ADR)的特点及其规律,指导临床用药的规范性、合理性。方法对318例合格ADR报告进行汇总分析,按照患者人群分布、给药途径、药品种类、涉及的系统或器官进行分类。结果静脉给药途径更易发生ADR,抗微生物类药物引发比例最高,头孢菌素类是引发ADR药物的主要类型,不良反应类型表现在呼吸系统反应最多。结论临床应合理掌握药物适应证,减少经静脉用药比例,尽可能避免ADR发生。

Objective To analyze the characteristics and pattern of adverse drug reaction （ADR） in our county in the recent 2 years, in order to make guide for the normalization and rationalization of clinical medication. Methods The reports of 318 ADR cases were summarized and analyzed, and they were classified by population distribution, drug delivery route, types of drug, and involved system or organ. Results The intravenous route was more susceptible for ADR. Antibiotics caused the highest proportion of ADR. Cephalosporin was the main type of ADR drugs. Adverse reactions happened mostly in the respiratory system. Conclusion Drug adaptation disease should be rationally control, and the proportion of intravenous medication should be reduced to avoid ADR.