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拉米夫定治疗慢性乙型肝炎相关耐药变异性因素分析

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摘要 目的探讨拉米夫定治疗慢性乙型肝炎相关耐药变异性因素。方法 100例慢性乙型肝炎患者作为研究对象,患者均服用拉米夫定治疗,患者接受72周治疗后对其耐药情况进行观察,并对其耐药变异性发生因素进行研究分析。结果 100例患者接受治疗后,发生耐药变异性患者31例(31%);治疗方案、患者ALT水平及HBV-DNA水平与相关耐药变异性发生因素有着直接关系(P<0.01)。结论治疗前对患者HBV-DNA水平及ALT水平进行详细准确检测,并探讨科学的治疗方案对于预防耐药性发生,促进患者康复有着重要的作用。
作者 张淑娥
出处 《中国现代药物应用》 2014年第18期130-131,共2页 Chinese Journal of Modern Drug Application
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