厄贝沙坦与依那普利治疗老年人高血压临床疗效观察

Clinical effect observation of irbesartan and enalapril in the treatment of senile hypertension

目的观察厄贝沙坦与依那普利治疗老年人高血压的临床疗效。方法 100例临床确诊为原发性高血压病的老年患者随机分为两组。观察组50例服用厄贝沙坦片150 mg/d,对照组50例服用依那普利片10 mg/d。治疗后4、8周分别测量血压,记录不良反应。结果治疗后4周观察组总有效率为88%,对照组总有效率为72%;治疗后8周观察组总有效率为94%,对照组总有效率为80%,两组总有效率比较差异有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论厄贝沙坦是治疗老年高血压病较好的药物。

Objective To observe the clinical effects of irbesartan and enalapril in the treatment of elderly patients with essential hypertension. Methods A total of 100 cases of elderly essential hypertension were randomly divided into 2 groups. 50 cases of the observation group received irbesartan 150 mg/d, and 50 cases of the control group were treated with enalapril 10 rng/d. Blood pressure and adverse reactions were measured in the 4th week and the 8th week of the treatment. Results In the 4 th week of the treatment, the total effective rate of the observation group was 88 %, and that of the control group was 72 %. In the 8th week, the total effective rate of observation group was 94 %, and that of control group was 80 %. The difference between the two groups had statistical significance （P〈0.05）. There-was no significant difference of adverse reactions between the two groups （P〉0.05）. Conclusion Irbesartan is the better drug in the treatment of senile hypertension.