摘要
为研究精神分裂症是机能性疾病,还是器质性疾病;后者是先天发育异常,还是后天脑损伤所致,我们选择33例分裂样精神病患者,对其脑脊液中的神经元特异性稀醇化酶(NSE)和髓鞘碱性蛋白(MBP)的含量,用双抗体夹心酶联法进行测定。结果: 1.阴性组、阳性组、对照组脑脊液中的NSE的含量分别为5.27±5.11ng/ml、2.36±1.27ng/ml、1.00±0.74ng/ml。阴性组与对照组比较有显著差异(P<0.05);阴性组与阳性组比较无显著性差异(P>0.05)。 2.阴性组、阳性组、对照组脑脊液中MBP的含量分别为0.35±0.49ng/ml、0.49±0.67ng/ml、0.15±0.21ng/ml。三组对照MBP无显著性差异(P>0.05)。 3.病例组脑脊液中NSE、MBP有相关性(rs=0.4533,P<0.01),阴性组NSF、MBP有相关性(rs=0.6177,P<0.05)。 研究结果支持分裂样精神病是后天各种因素所致的脑损伤疾病。
In order to study whether schizophrenia was funtional disease or brain orgaic one whose cause was congenital dysplasia or acquired cerebral injury, 33 cases of schizophrenform psychoses. The determinations of neruon-specific enolase (NSE) and myelin basic protein (MBP)in the cerebrospinal fluid (CSF)of those 33 cases were made by double antibody sandwicn enzyme immunassay method. Results showed as follows;1. NSE contents of CSF were respectively 5. 27±5. ling/ml. 2. 36±1. 27ng/ml and 1. 00±0. 74ng/ml in negative, positive and control groups. There was significant importance in content of the negative in comparison with that of the control (p<0. 01);so did the Positive with the Control(p<0. 05);there were no significant diffrence between the positive and negative(p>0.05).2. MBP contents of CSF were respectively 0. 35±0. 49ng/ml,0. 49±0. 67ng/ml,0. 15±0. 21ng/ml in negative ,positive and control groups. There were no significant difference in the negative)positive and control. (p> 0. 05)3. CSF-NSE was Correlated with CSF-MBP in (case)group (r = 0. 4533,P<0. 0.1) and in in the negative group(r = 0. 6177,P<0. 05),The results suggested that schizophreniform psychosis was the cerebral injury which was caused by acquired factors.