期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SIRT蛋白功能研究进展 被引量：2

下载PDF
导出
摘要 Sirtuins蛋白是一种烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide，NAD＋）依赖的组蛋白去乙酰化酶。酵母Sirtuins与染色体末端的失活及rDNA转录沉默有关，可以延缓抑制衰老，延长寿命。Sirtuins是一个高度保守的基因家族，它不仅存在于酵母、果蝇、秀丽线虫等细胞内，还广泛存在于哺乳动物各种细胞内。至今为止，人类细胞内已经发现了7种不同类型的Sirtuins（SIRT）蛋白，分别命名为SIRT1～7。
作者 周娜静 闫永鑫 徐彦楠 闫蕴力
机构地区 河北医科大学基础医学研究所细胞生物研究室
出处 《河北医科大学学报》 CAS 2014年第8期983-986,共4页 Journal of Hebei Medical University
关键词 抗衰老酶 蛋白 综述文献
分类号 R345.54 [医药卫生—基础医学]
  • 相关文献

参考文献21

  • 1SINCLAIR DA, LINL SJ, GUARENTE L. Life-span extension in yeast [ J ]. Science,2006,312 ( 5771 ) : 195 - 197.
  • 2CHAKRABARTI P, ENGLISH T, KARKI S, et al. SIRT1 controls lipolysis in adipocytes via FOXOl-mediated expression of ATGL [J]. J Lipid Res,2011,52(9) :1693 -1701.
  • 3PONUGOTI B, KIM DH, XIAO Z, et al. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism [ J ]. J Biol Chem,2010,285 (44) :33959 - 33970.
  • 4CHEN HC, JENG YM, YUAN RH, et al. SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis [ J ]. Ann Surg Oncol,2012,19(6) :2011 -2019.
  • 5BRUNET A, SWEENEY LB, STURGILL JF, et al. Stress- dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [ J ]. Science,2004,303 (5666) :2011 - 2015.
  • 6马静静,郭淑芹,张云良,李志红,张金库,周炳娟,朱春英.结直肠癌中沉默信息调节因子1与耐药基因的表达及临床意义[J].临床荟萃,2012,27(24):2145-2148. 被引量：6
  • 7KIM JR, MOON YJ, KWON KS, et al. Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas [J]. PLoS One,2013,8(9):e74738.
  • 8WU M, WEI W, XIAO X, et al. Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer [ J ]. Med Oncol,2012,29(5 ) :3240 - 3249.
  • 9FENG AN,ZHANG LH, FAN XS, et al. Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance [ J ]. Int J Surg Pathol,2011,19(6) :743 -750.
  • 10WU ML, LI H, YU LJ, et al. Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells[ J ]. PLoS One,2014,9 (2) : e89806.

二级参考文献8

  • 1Pruitt K, Zinn R1, Ohm JE, et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation[J]. PLOS Genet, 2006,2 (3) : e40.
  • 2Chu F, Chou PM, Zheng X, et al. Control of multidrug resistance gene mdrl and cancer resistance to chemotherapy by the longevity gene sirtl [J]. Cancer Res, 2005,65 ( 22 ) : 10183- 10187.
  • 3Li Y, Tollefsbol TO. P16 (INK4a)suppression by glucose restriction contributes to human celluar life span extension through SIRTl-mediated epigenetic and genetic mechanism [J]. PLos One,2011,6(2) :e17421.
  • 4Wu M,Wei W,Xiao X,et al. Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negtive and non-triple-negative breast cancer [J]. Med Oneol,2012,June 4.
  • 5Firestein R,Blander G, Miehan S, et al. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth [J].PLoS ONE,2008,3(4) :e2020.
  • 6Olmos Y, Brosens JJ, Lam EW. Interplay between SIRT1 proteins and tumor suppressor transcription factors in chemotherapeutic resisitance of cancer[J]. Drug Resist Updat, 2011,14(1):35-44.
  • 7Ford J,Jiang M, Milner J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival[J]. Cancer Res,2005,65(22) : 10457-10463.
  • 8Liu T,Liu PY, Marshall GM. The critical role of the class Ⅲ histone deacetylase SIRT1 in cancer[J]. Cancer Res, 2009,69 (5) : 1702-1705.

共引文献5

同被引文献2

引证文献2

二级引证文献3

河北医科大学学报
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部