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丁香苦苷PLGA纳米粒的体外释放研究 被引量:1

Study on release in vitro of Syringopicroside PLGA nanoparticles
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摘要 为研究丁香苦苷PLGA纳米粒(SYR-NP)的体外释药规律,采用动态透析技术考察SYRNP体外释药性能,并用高效液相测定SYR-NP和SYR溶液的含量,以累积释药百分率进行不同模型的拟合.SYR-NP的体外释放规律基本符合Higuchi方程的释药模型,拟合的释药动力学方程为Q=0.128 1+0.018 9t1/2(r=0.956 8).相比于药物溶液,SYR-NP具有良好的缓释的作用. In order to study the vitro release profile of Syringopicroside PLGA nanoparticles , the dynamic dialysis technology was employed to study the in vitro release ability of SYR -NP and Syringopicroside solution .The content of Syringopicroside was determined by HPLC , and the fitting of different models were performed based on the accumulative drug release percentages .The release curve of Syringopicroside PLGA nanoparticles was in line with Higuchi equation , Q=0.128 1+0.018 9t1/2 ( r=0.956 8) .Compared with the Syringopi-croside solution , SYR-NP has a satisfactory sustained release effect .
出处 《哈尔滨商业大学学报(自然科学版)》 CAS 2014年第4期395-397,401,共4页 Journal of Harbin University of Commerce:Natural Sciences Edition
基金 国家自然基金面上项目(81274091)
关键词 丁香苦苷 PLGA纳米粒 体外释放 Syringopicroside PLGA nanoparticles:drug release in vitro
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  • 1何林,余继英,张丽,李素华,蒋学华.阿克拉霉素A固体脂质纳米粒冻干针剂体外释药规律研究[J].中国药房,2004,15(9):533-535. 被引量:6
  • 2Wang D D Liu S Q Chen Y J et a1.Studies on the active constituents of Syringa oblata Lindl [J].Acta Pharm Sin(药学学报),1982,17(12):951-954.
  • 3Department of Infectious Diseases of First Hospital of Jilin University of Medical Sconces.The preparation and clinical effect on icterohepatitis of Dingxiang Tablets[J].Chin Tradit Herb Drugs(中草药),1978,(1):18-18.
  • 4DEREK T,MANMOHAN S, RAJESH K. Poly( lactide-co-glycolide) micropartlcles for the development of single-dose controlled- release vaccines[ J]. Adv Drug Deliv Rev, 1998,32 (10) :225 - 246.
  • 5LEACH WT,SIMPSON DT,VAL TN,et al. Uniform encapsulation of stable protein nanoparticles produced by spray freezing for the reduction of burst release[ J]. J Pharm Sci,2005,91 (1) : 56 - 69.
  • 6MAO SR,XU J,CAI CF,et al. Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres[J], lnt J Pharm,2007,334(1 -2):137 - 148.
  • 7SCHLICHER EJAM,POSTMA NS,ZUIDEMA J,et al. Preparation and characterization of poly(d,l-lactic-co-glycolic acid) mi- crospheres containing desferrioxamine [ J ]. lnt J Pharm, 1997, 153:235 - 245.
  • 8LEE YS,LOWE JP,GILBY E,et al. The initial release of eisplatin from poly ( lactide-co-glycolide microspheres [ J ]. lrtt J Pharm ,2010,383 ( 1 - 2 ) :244 - 254.
  • 9BERKLAND C,KIM K,PACK DW. PLGA microsphere size controis drug release rate through several competing factors [ J ]. Pharm Res,2003,20(7) : 1055 - 1062.
  • 10BERKLAND C, KING M, COX A,et al. Precise control of PLG microsphere size provides enhanced control of drug release rate [ J ]. J Control Release,2002,82 ( 1 ) : 137 - 147.

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  • 1张臻,宋芹,胡慧玲,何瑶,傅超美.美洲大蠊提取物的质量标准研究[J].中药与临床,2013,4(5):20-21. 被引量:8
  • 2蒋永新,王熙才,金从国,袁方,刘光明,李树楠.康复新体外诱导胃癌BGC-823细胞凋亡的实验研究[J].昆明医学院学报,2006,27(2):5-9. 被引量:51
  • 3蒋永新,王熙才,金从国,陈晓群,李佳,伍治平,刘光明,李树楠.美洲大蠊提取物对小鼠3LL肺癌的抑制作用及其机制探讨[J].中国肺癌杂志,2006,9(6):488-491. 被引量:34
  • 4Makadia H K, Siegel S J. Poly Lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier [J]. Polymers, 2011, 3(3): 1377-1397.
  • 5Danhier F, Ansorena E, Silva J M, et al. PLGA-based nanoparticles: An overview of biomedical applicatioias [J]. J Controlled Release, 2012, 161(2): 505-522.
  • 6Rieux A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach [J]. J Controlled Release, 2006, 116(1): 1-27.
  • 7Florence A T. Nanoparticle uptake by the oral route: Fulfilling it's potential? [J]. Drug Discov Today, 2005, 1 (2): 75-81.
  • 8Carino G P, Jacob J S, Mathiowitz E. Nanosphere based oral insulin delivery [J]. J Controlled Release, 2000, 65(1/2): 261-269.
  • 9Panyam J, Dali M M, Sahoo S K, et al. Polymer degradation and in vitro release of a model protein from Poly (D,L-laetide-co-glycolide) nano and micro particles [J]. ,I Controlled Release, 2003, 92(1/2): 173-187.
  • 10Pan y, Zhao H, Xu H, et al, Effect of experimental parameters on the encapsulation of insulin-loaded poly (laetide-co-glycolide) nanoparticles prepared by a double emulsion method [J]. J Chin Pharm Sci, 2002, 11(1):38-41.

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