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丁香苦苷PLGA纳米粒的体外释放研究 被引量：1

Study on release in vitro of Syringopicroside PLGA nanoparticles
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摘要 为研究丁香苦苷PLGA纳米粒(SYR-NP)的体外释药规律,采用动态透析技术考察SYRNP体外释药性能,并用高效液相测定SYR-NP和SYR溶液的含量,以累积释药百分率进行不同模型的拟合.SYR-NP的体外释放规律基本符合Higuchi方程的释药模型,拟合的释药动力学方程为Q=0.128 1+0.018 9t1/2(r=0.956 8).相比于药物溶液,SYR-NP具有良好的缓释的作用. In order to study the vitro release profile of Syringopicroside PLGA nanoparticles , the dynamic dialysis technology was employed to study the in vitro release ability of SYR -NP and Syringopicroside solution .The content of Syringopicroside was determined by HPLC , and the fitting of different models were performed based on the accumulative drug release percentages .The release curve of Syringopicroside PLGA nanoparticles was in line with Higuchi equation , Q=0.128 1＋0.018 9t1/2 （ r=0.956 8） .Compared with the Syringopi-croside solution , SYR-NP has a satisfactory sustained release effect .
作者 封文静 管庆霞 张亮 李梦雪 李永吉
机构地区 黑龙江中医药大学
出处 《哈尔滨商业大学学报（自然科学版）》 CAS 2014年第4期395-397,401,共4页 Journal of Harbin University of Commerce：Natural Sciences Edition
基金 国家自然基金面上项目(81274091)
关键词 丁香苦苷 PLGA纳米粒 体外释放 Syringopicroside PLGA nanoparticles：drug release in vitro
分类号 R283 [医药卫生—中药学]
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共引文献30

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哈尔滨商业大学学报（自然科学版）
2014年 第4期

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