氨磺必利与氯氮平对首发精神分裂症患者社会功能的影响

Effects of amisulpride and clanzapine on social function of pa-tient with first-episode schizophrenia

目的：探讨氨磺必利与氯氮平对首发精神分裂症患者社会功能的影响。方法将100例首发精神分裂症患者随机分为两组，每组50例，研究组口服氨磺必利治疗，对照组口服氯氮平治疗，观察12周。于治疗前后采用阳性与阴性症状量表评定精神症状，个人与社会功能量表评定社会功能。结果治疗后两组阳性与阴性症状量表总分及各因子分均较治疗前显著下降（P＜0．01），同期两组评分比较差异无显著性（P＞0．05）；治疗后两组个人与社会功能量表总分均较治疗前显著升高（P＜0．01），研究组较对照组升高更显著（P＜0．05）。结论氨磺必利与氯氮平均能够改善精神分裂症患者的阳性、阴性症状，但氨磺必利改善患者的社会功能显著优于氯氮平。

Objective To explore the effects of amisulpride and clanzapine on social function of patient with first-episode schizophrenia .Methods A total of 100 patients with first-episode schizophrenia were randomly divided into two groups of 50 ones each ,research group took orally amisulpride and control group did clanzapine for 12 weeks .Efficacies were assessed with the Positive and Negative Syndrome Scale （PANSS） and social functions with the Personal and Social Performance Scale （PSP） .Results After treatment total scores and each factor scores of PANSS of both groups lowered more significantly compared with pretreatment （P〈0 .01） ,those had no significant group differences in the corresponding period （P〉0 .05）;After treatment the PSP total scores of both groups heightened more significantly （P〈0 .01） ,so did those in research than control group （P〈0 .05） .Conclusion Both amisulpride and clozapine could im-prove positive and negative symptoms of schizophrenic ,but the former has an advantage in social functions over the latter .