急性脑梗塞伴高尿酸血症患者凝血功能变化及其临床意义

Changes of coagulation function in cute cerebral infarction patients with hyperuricemia and its clinical significance

目的:探讨急性脑梗塞伴高尿酸血症患者凝血功能变化及其临床意义。方法:60例经高分辨率影像学确诊为急性脑梗塞患者根据血尿酸水平分为实验组高尿酸血症组A组;实验组非高尿酸血症组B组;同一时期60例非脑梗塞患者作为对照组C组,所有患者均检测血尿酸、凝血检查及D-二聚体,三组数据进行比较分析。结果:血FIB、TT、D-二聚体在实验组A明显高于实验组B,实验组明显高于对照组C(P<0.05);APTT、PT在实验组A组明显低于实验组B组,实验组明显低于对照组(P<0.05)。结论:高尿酸血症促进急性脑梗塞患者体内凝血功能异常,表现为纤溶活性下降,血小板粘附聚集作用增强,血栓形成;急性脑梗塞患者在急诊救治中应重视高尿酸血症的防治和监测。

Objective：To analyze the changes of coagulation function in acute cerebral infarction patients with hyperurieemia and investigate its clinical significance. Method： 60 cases of acute cerebral infarction patients diagnosed by high-resolution imaging were divided into experimental hyperuricemia Group A, experimental group of non hyperuricemia Group B according to serum uric acid levels. Same period,60 cases of non-infarction patients in group C as the control group. All patients were detected in serum uric acid,blood clotting inspection and D-dimer. Three sets of data were collected for comparative analysis. Result： Blood FIB, TT, D-dimer in the experimental group A was significantly higher than the experimental group B, the experimental group was significantly higher than C （P〈0.05） ;APTT,PT in the experimental group A was significantly lower than the experimental Group B, experimental group was significantly lower than the control group （P〈0.05）. Conclusion： Hyperuricemia in patients with acute cerebral infarction promotes coagulation dysfunction,manifested as decreased fibrinolytic activity, the enhanced role of platelet adhesion and aggregation, thrombosis. In the emergency treatment of acute cerebral infarction patients should pay attention to prevention,treatment and monitoring of hyperuricemia.