期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD4^+调节性T细胞与再生障碍性贫血发病机制的关系 被引量：2

下载PDF
导出
摘要 调节性T细胞（regulatory T cells,Treg）是具有免疫调节功能的T细胞亚群,包含CD4＋T细胞、CD8＋T细胞、CD4-CD8-T细胞及部分自然杀伤细胞等。Treg不仅在自身免疫耐受的获得和维持及自身免疫防御中起着重要作用,而且在肿瘤、移植耐受甚至是病原体感染等免疫反应调节中也扮演重要角色。
作者 齐薇薇 邵宗鸿
机构地区 天津医科大学总医院血液科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2014年第9期1263-1267,共5页 Chinese Journal of Immunology
基金 国家自然科学基金(81170472 81370607) 天津市自然科学基金重点项目(12JCZDJC21500) 天津市抗癌重大专项攻关计划(12ZCDZSY17900 12ZCDZSY18000) 天津市卫生行业重点项目(11KG135) 卫生行业科研专项项目(201202017)
关键词 CD4 再生障碍性贫血 移植耐受 免疫防御 免疫反应 细胞活化 免疫调节功能 自然杀伤细胞 抑制作用 抗原特异性
分类号 R556.5 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献34

  • 1Zatz MM, Gershon RK. Regulation of lymphocyte trapping: the negative trap [ J ]. J Immunol, 1975,115 ( 2 ) :450-453.
  • 2Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self- tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ( CD25 ) : Breakdown of a single mechanism of self- tolerance causes various autoimmune diseases [ J ]. J Immunol,1995,155(3) :1151-1164.
  • 3Lio CW, Hsieh CS. A two-step process for thymic regulatory T cell development [ J ]. Immunity, 2008,28 ( 1 ) : 100-111.
  • 4Fu CL,Chuang YH,Huang HY,et al. Induction of IL-IO producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells [ J ]. Clin Exp Immunol,2008,153 ( 2 ) :258-268.
  • 5Passerini L, Di Nunzio S, Gregori S, et al. Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome [ J ]. Eur J Immunol, 2011,41 ( 4 ) : 1120-1131.
  • 6Veldman C, Pahl A, Hertl M. Desmoglein 3-specific T regulatory 1 cells consist of two subpopulations with differential expression of the transcription factor Foxp3 [ J] . Immunology, 2009, 127 ( 1 ) : 40-49.
  • 7Carrier Y,Yuan J,Kuchroo VK,et al. Th3 cells in peripheral toler- ance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice [ J ]. J Immunol, 2007 ; 178 ( 1 ) : 179-185.
  • 8Huter EN, Punkosdy GA, Glass DD, et al. TGF-beta-induced Foxp3 regulatory T cells rescue scurfy mice [ J ]. Eur J Immunol, 2008,38 (7) : 1814-1821.
  • 9Lan Q,Zhou X,Fan H,et al. Polyclonal CD4+Foxp3+ Treg cells induce TGFI3-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome [ J ]. J Mol Cell Biol,2012,4 (6) : 409-419.
  • 10Wing K, Onishi Y, Prieto-Martin P,et al. CTLA-4 control over Foxp3+ regulatory T cell function [ J 1. Science, 2008, 322 (5899) :271-275.

二级参考文献30

  • 1邵宗鸿,袁烨.再生障碍性贫血免疫发病机制及免疫治疗[J].中国实用内科杂志：临床前沿版,2006,26(2):252-255. 被引量：83
  • 2涂梅峰,邵宗鸿,刘鸿,何广胜,付蓉,施均,白洁,曹燕然,王化泉,邢莉民,崔振珠,孙娟,贾海蓉,陈辉树,薛艳萍,杨崇礼.重型再生障碍性贫血患者Th3细胞、调节T细胞数量和转化生长因子β1的水平[J].中华血液学杂志,2006,27(11):753-756. 被引量：22
  • 3Sakaguchi S, Sakaguchi N, Asano M, et al. Immunological self-tolerance maintained by activated T cells expression IL-2 receptor alpha-chains( CIY25 ). Breakdown of a single mechanism of self-tolerance causes various autoimmune disease. J Immunol, 1995, 155: 1151-1164.
  • 4Viglietta V, Baecher-Allan C, Weiner HL,et al. Loss of functional suppression by CD4^+ CD25^+ regulatory T cells in patients with multiple sclerosis. J Exp Med, 2004, 199: 971-979.
  • 5Balandina A, Lecart S, Dartevelle P,et al. Functional defect of regulatory CD4( + )CD25 ( + ) T cells in the thymus of patients with autoimmune myasthenia gravis. Blood, 2005, 105:735-741.
  • 6Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun, 2003, 21: 273-276.
  • 7Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity, 2003, 19:165-168.
  • 8Liu W, Putnam AL, Xu-Yu Z,et al. CD127 expression inversely correlates with Foxp3 and suppressive function of human CD4 + Treg cells. J Exp Med, 2006, 203:1701-1711.
  • 9Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med, 2006, 203: 1693-1700.
  • 10Tournoy J, Bossuyt X, Snellinx A, et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mo Genet, 2004, 13 : 1321-1331.

共引文献28

同被引文献21

  • 1韩悦,吴德沛,金正明,孙爱宁,何广胜,陈苏宁,王秀丽,卢晓旭.抗CD33单抗联合造血干细胞移植治疗难治继发性急性髓系白血病一例[J].中华血液学杂志,2006,27(1):31-31. 被引量：2
  • 2Larson RA. Etiology and management of therapy-related myeloid leukemia [J]. Hematology Am Soc Hematol Educ Program, 2007: 453-459.
  • 3Spina F, Alessandrino PE, Milani R, et al. Allogeneic stem cell transplantation in therapy-related acute myeloid leukemia and myelodysplastic syndromes: impact of patient characteristics and timing of transplant [J]. Leuk Lymphoma, 2012, 53 ( 1 ): 96- 102.
  • 4Litzow MR, Tarima S, P6rez WS, et al. Allogeneic transplanta- tion for therapy-related myelodysplastic syndrome and acute myeloid leukemia[J]. Blood, 2010, 115(9): 1850-1857.
  • 5Morrison VA, Rai KR, Peterson BL, et al. Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011 [J]. J Clin Oncol, 2002, 20 (18): 3878- 3884.
  • 6Fianchi L, Criscuolo M, Lunghi M, et al. Outcome of therapy- related myeloid neoplasms treated with azacitidine [J]. J HematolOncol,2012,5:44.
  • 7Ueno NT, Rond6n G, Mirza NQ, et al. Allogeneic peripheral- blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer [ J ]. J Clin Oncol, 1998, 16 (3): 986-993.
  • 8Stern M, de Wreede LC, Brand R, et al. Sensitivity of hematolog- ical malignancies to graft-versus-host effects: an EBMT mega- file analysis [ J ]. Leukemia, 2014, 28 ( 11 ): 2235-2240.
  • 9Pievani A, Borleri G, Pende D, et al. Dual-functional capability ofCD3+CD56+ CIK cells, a T-cell subset that acquires NK func- tion and retains TCR-mediated specific cytotoxicity [J]. Blood, 2011, 118(12): 3301-3310.
  • 10Yang B, Wang J, Cai LL, et al. Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells[J]. Cytotherapy, 2014, 16(2): 278-284.

引证文献2

二级引证文献2

中国免疫学杂志
2014年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部