维生素D受体基因Taq I位点多态性与泌尿系结石关系的Meta分析

Meta-Analysis of association between Vitamin D receptor gene Taq I loci polymorphism and Urinary calculus

目的探究维生素D受体基因Taq I位点多态性与泌尿系结石的相关性。方法计算机检索Pubmed、Sciencedirect、中国知网、万方数据库,并筛选出研究维生素D受体基因Taq I位点多态性与泌尿系结石关系的病例对照研究,同时在结果中查阅相关参考文献,检索时间为建库至2013年11月23日。检索及数据提取由2名人员单独进行,采用StataSE12.0进行Meta分析及其他统计学分析。结果共纳入9篇符合要求的文献,Meta分析结果显示,整体效应下显性模型有统计学意义,OR=1.31,95%CI(1.01,1.69),其他模型在整体效应下均无统计学意义。结论维生素D受体基因Taq I位点显性基因与泌尿系结石的发病存在相关性,其他基因模型与泌尿系结石的发病没有相关性。

Objective It is to analyze the relationship between VDR gene Taq I loci polymorphism and Urinary calculus. Method Pubmed, Sciencedirect, CNKI, WangFang database were searched to collect case control studies on association between Taq I loci polymorphism of VDR gene and Urinary calculus from establish to November 23, 2013 and the relevant references were consulted in the results at the same time. The search and data extraction were accomplished by two people independently and StataSE12.0 software was used for meta Meta-analysis and other statistic analysis. Results 9 case-control stud- ies were included . The final Meta-analysis result showed that there were significant correlations between Vitamin D receptor gene Taq I loci polymorphism and Urinary calculus in dominant gene model（ OR = 1.31,95 % CI （ 1.01,1.69 ） ） and no significant correlation in other gene models. Conclusion Dominant gene of Vitamin D receptor gene Taq I is related to urinary calculus and other gene models not.