射频治疗胃食管反流改善老年患者支气管哮喘症状的临床研究

The Clinical Study of the Effect of Radiofrequency Therapy in the Asthma Symptom of Elderly Patients with Gastroesophageal Reflux Disease

目的探讨支气管哮喘(哮喘)与胃食管反流症(gastroesophageal reflux disease,GERD)的相关性,以及射频抗反流治疗对老年哮喘患者呼吸系统症状的改善作用。方法选择合并GERD的老年哮喘患者124例,随机分为3组,即药物组(奥美拉唑20 mg,每日3次)42例,射频组34例及对照组(不治疗)48例,对所有患者进行为期2年的随访,观察患者肺功能变化及服用药物种类、剂量等变化情况。结果射频组哮喘症状明显改善,括约肌静止压、哮喘得分及反流得分均优于药物组及对照组(P<0.05),且2年随访期内射频组情况持续改善,但3组间药物服用种类及剂量方面比较差异无统计学意义(P>0.05)。结论对合并GERD的老年哮喘患者,成功的抗反流治疗能够明显改善肺功能状态。

Objective To investigate the relationship between bronchial asthma and gastroesophageal reflux disease （GERD）, and observe the effect of radiofrequency （ RF） therapy in the asthma symptom of old patients with GERD. Methods A total of 124 elderly patients with asthma and GERD were randomly divided into three groups：the drug group （42 patients, Omeprazole 20 mg, 3/d）, RF group （34 patients） and control group （48 patients, no treatment）. All patients were followed up for two years to observe the changes of pulmonary function and drug types and dosage. Results Asthma symptoms in RF group improved significantly. Sphincter resting pressure, asthma and reflux scores were all better than those in the drug group and the control group （P〈0. 05）, and in the 2-year follow-up, the improvements in RF group continued, but there were no significant differences among the three groups in the types and dosage of drug taken by the patients （P〉0. 05）. Conclusion Successful anti-reflux therapy in treatment of elderly patients with GERD and asthma can significantly improve lung function state.