醒脑静联合血塞通治疗急性脑梗死的临床观察

Clinical observation of Xingnaojing combined with Xuesaitong in the treatment of cerebral infarction

目的比较醒脑静联合血塞通和依达拉奉联合血塞通治疗脑梗死的临床疗效。方法选取2012年3月至2013年11月海南省农垦那大医院和海南省中医院收治的54例脑梗死患者,按照随机数字表法将其分为试验组和对照组各27例,试验组患者应用醒脑静注射液联合血塞通治疗,对照组患者应用依达拉奉注射液联合血塞通治疗。观察两组患者治疗前、治疗14 d和21 d的血清丙二醛(MDA)、超氧化物歧化酶(SOD)和白三烯的动态改变。以神经功能缺损评分(ESS)和日常生活能力缺陷评分(ADL)以增分率判断两组患者的疗效。结果试验组和对照组的有效率分别为77.78%和37.04%,其差异具有统计学意义(χ2=9.552,P=0.023);试验组不同时间点MDA、SOD及白三烯的变化差异均有统计学意义(F=18.65,P<0.001;F=11.54,P<0.001;F=13.45,P<0.001);对照组MDA及SOD不同时间点差异也具有统计学意义(F=6.65,P=0.035;F=5.87,P=0.043);两组患者MDA、SOD及白三烯比较差异具有统计学意义(F=9.65,P=0.009;F=8.76,P=0.011;F=6.73,P=0.032);并且两组患者不同时间点MDA、SOD及白三烯差异也均具有统计学意义(F=7.03,P=0.028;F=5.96,P=0.043;F=5.67,P=0.046)。结论醒脑静联合血塞通治疗脑梗死的疗效较好。

Objective To discuss the therapeutic effect of Xingnaojing combined with Xuesaitong in the treatment of patients of cerebral infarction. Methods All 54 patients were collected from March 2012 to November 2013 in Hainan Nongken Nada Hospital and Hainan Provincial Hospital of Traditional Chinese Medicine. According to random number table, the patients were divided into two groups. The study group applied Xingnaojing injection combined with Xuesaitong, and the control group used edaravone injection combined with Xuesaitong. Dynamic changes were observed with malonyldialdehyde （MDA）, superoxide dismutase （SOD） and leukotrienes in two groups before treatment,14 d and 21 d after treatment. ESS and ADL was applied to assess the clinical efficacy. Results The effective rate of was 77.78%in the study group and 37.04%in the control group, with statistically significant difference （χ^2=9.552, P=0.023）. The difference was statistically significant in MDA, SOD, and leukotrienes at different time points in the study group （F=18.65, P〈0.001;F=11.54, P〈0.001;F=13.45, P〈0.001）. The difference was statistically significant in MDA, SOD at different time points in the control group （F=6.65, P=0.035;F=5.87, P=0.043）. Statistically significant differ-ence was found in MDA, SOD, and leukotrienes between the two groups （F=9.65, P=0.009; F=8.76, P=0.011; F=6.73, P=0.032）. The difference was also statistically significant in MDA, SOD, and leukotrienes at different time points between the two groups （F=7.03, P=0.028;F=5.96, P=0.043;F=5.67, P=0.046）. Conclusion The therapeutic effect of Xingnaojing combined with Xuesaitong is better for patients of cerebral infarction.