小剂量泼尼松联合雷公藤多甙、复方甘草酸苷治疗湿疹的疗效观察

Efficacy of low-dose prednisone combined with tripterygium glycosides and compound Glycyrrhizin in the treatment of eczema

目的探讨小剂量泼尼松联合雷公藤多甙、复方甘草酸苷治疗泛发性和/或中、重度湿疹的疗效。方法 97例泛发性和/或中、重度湿疹患者随机分为泼尼松组(32例)、雷公藤多甙组(32例)以及联合治疗组(33例),分别予泼尼松+复方甘草酸苷、雷公藤多甙+复方甘草酸苷以及泼尼松+雷公藤多甙+复方甘草酸苷治疗,疗程两周。结果治疗一周后,三组的有效率比较差异有显著统计学意义(P<0.01),且联合治疗组的有效率均显著高于泼尼松组和雷公藤多甙组(P<0.01)。治疗两周后,三组的痊愈率比较差异有显著统计学意义(P<0.01),且联合治疗组的痊愈率均高于泼尼松组和雷公藤多甙组(P<0.05)。结论小剂量泼尼松联合雷公藤多甙、复方甘草酸苷治疗泛发性和/或中、重度湿疹疗效肯定、副作用少、便于管理,可在社区和门诊推广。

Objective To investigate the efficacy of low-dose prednisone combined with tripterygium glyco-sides and compound glycyrrhizin in the treatment of generalized and/or moderate to severe eczema. Methods Ninety-seven patients with eczema were randomly divided into prednisone group （n=32, treated with prednisone and compound glycyrrhizin for 2 weeks）, tripterygium glycosides group （n=32, treated with triptergium glycosides and compound glycyrrhizin for 2 weeks） and combined therapy group （n=33, treated with prednisone, tripterygium glycosides and compound glycyrrhizin for 2 weeks）. Results The effective rates were significantly different among three groups （P〈0.01） after 1 week of treatment. The effective rate in combined therapy group was higher than those in the other two groups （P〈0.01）. After 2 weeks, the cure rate of the three groups were also significantly different （P〈0.01）, and the cure rate in combined therapy group was higher than those in the other two groups （P〈0.05）. Conclusion Treat-ment of generalized and/or moderate to severe eczema with prednisone, tripterygium glycosides and compound glycyrrhizin has many benefits, with high efficacy and few adverse reactions. It can be practised in community and outpatient department.