A型肉毒毒素重复治疗偏头痛的临床疗效

Therapeutic effect of repeated injections of botulinum toxin type A in treatment of migraine

目的 探讨A型肉毒毒素重复注射治疗偏头痛的疗效与安全性。方法 对30例偏头痛患者均进行2次A型内毒毒素注射治疗，两次均采用颅周固定位点注射，初次治疗间隔6个月以上后进行第2次治疗，2次治疗后分别于第1，2，3个月评定头痛发作天数、头痛发作次数、疼痛程度、偏头痛残疾程度及不良反应。结果 二次A型肉毒毒素注射治疗后偏头痛发作天数、发作次数、疼痛程度、残疾程度均较治疗前缓解（F分别为3．86，5．23，9．37，5．67；P〈0．05），但两次治疗后各观察点评定指标比较差异无统计学意义（P〉0．05）。结论 A型肉毒毒素重复治疗偏头痛有效、安全，较初次治疗无差异．

Objective To observe the clinical efficacy and safety of the repeated injections of botulinum toxin type A in the treatment of Migraine. Methods Totals of 30 cases of patients with migraine were secondary injection of botulinum toxin type A treatment after initial treatment interval in June for the second treatment. Days of headache, frequency of headache, headache intensity （evaluated by visual analogue scale, VAS） ,migraine disability（evaluated by migraine disability assessment guestionnaire, MIDAS） and adverse reactions were assessed on 1 month before the treatment and l st,2st,3st months after the treatment. Results After the secondary injection of botulinum toxin type A treatment, days of headache, frequency of headache, headache intensity and migraine disability than before treatment remission （P 〈 0.05）, But the secondary treatment in each observation point evaluation index are no statistically significant difference （P 〉0. 05）. Conclusions Botulinum toxin type A repeated treatment of migraine is effective, relative safe and no difference compared to the initial treatment.