肥胖患者血清C-反应蛋白与胰岛素抵抗相关性

Discuss the focus on the relativity between the C-reactive protein(CRP) and the insulin resistance on the obese patients

目的:探讨肥胖患者的血清C-反应蛋白(CRP)与胰岛素抵抗相关性。方法:测定观察对象的空腹血糖(FBG)、空腹胰岛素(FINS、2h血糖(2hBG)、体重、身高,计算胰岛素抵抗指数(Homa-IR)和体重指数(BMI)。根据BG和BMI分为正常对照组36例,单纯肥胖组36例,肥胖并2型糖尿病组36例。用免疫透射比浊法测定血清CRP水平。结果:与正常对照组相比,单纯肥胖组和肥胖并2型糖尿病组CRP和Homa-IR升高,差异有统计学意义(P<0.05)。与单纯肥胖组相比,2型糖尿病组CRP和Homa-IR升高,差异有统计学意义(P<0.05)。经过相关分析CRP与Homa-IR和BMI呈显著正相关。结论:肥胖患者存在低度慢性炎性反应和糖代谢密切相关。

Objective To discuss the focus on the relativity between the C-reactive protein（CRP） and the insulin resistance on the obese patients.Methods The authors determine the fasting blood glucoses,fasting insulins,2h blood glucoses,the weights and the heights of the patients,and calculate the Homa-IR and the BMI.According to the BG and BMI,there are three groups 36 examples of normal adults,36 examples of obese patients and 36 examples of obese patients with type 2 diabetes.The CRP is detect by Immune turbidimetric.Results Compared with the result of the normal adults,the result of CRP and Homa-IR are higher on the obese patients and obese patients with type 2 diabetes.The difference are statistical significance（P〈0.05）.And the result of CRP and Homa-IR on the obese patients with type 2 diabetes are higher than the Results of obese patients.The difference are statistical significance（P〈0.05）.The CRP and Homa-IR are actually in proportion to the BMI.Conclusion This paper shows that the reason why the diabetics have low-grade chronic inflammation is closely related to theglucose metabolism.