不同剂量阿托伐他汀治疗老年冠心病的临床疗效分析

Clinical effect of different doses of atorvastatin in the treatment with coronary heart disease

目的探讨不同剂量阿托伐他汀治疗冠心病的临床效果。方法选取本院收治的60例冠心病患者,按随机双盲原则分为低剂量组(20 mg/d)和高剂量组(40 mg/d),每组30例,疗程为16周,观察并比较两组患者的降脂效果及安全性。结果高剂量组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显降低,高密度脂蛋白胆固醇(HDL-C)水平明显升高,与低剂量组比较差异具有显著性(P<0.05)。高剂量组疗效明显提高,不良心脑血管事件发生率明显降低,与低剂量组比较差异具有显著性(P<0.05)。结论 40 mg/d剂量阿托伐他汀治疗冠心病效果显著,安全性好,值得临床推广。

Objective To observe the clinical effect of different doses of atorvastatin in the treatment with coronary heart disease. Method 60 patiens with oronary heart disease were randomly divided into the low dose group （20 mg/d） and high dose group （40 mg/d） 30 cases for each group, treated with atorvastatin for 16 weeks. The changes of blood lipid and safety in two groups were observed. Result After treatment, serum TC, TG and LDL-C levels of high dose group were significantly decreased, HDL-C levels of high dose group were significantly increased, showed significant differences between the two groups （P 〈 0.05）. The curative effect of high dose group was significantly increased, MACCE of high dose group was significantly decreased, showed significant differences between the two groups （P 〈 0.05）. Conclusion 40 mg/d atorvastatin, safety and marked efficacy in treatment with coronary heart disease, is worth clinical promotion.