烧伤感染和抗生素的合理使用探讨

Burn infection and rational use of antibiotics

目的探讨在临床药师的配合指导下合理应用抗生素对烧伤患者的临床疗效。方法 138例烧伤患者按入院顺序分为对照组(68例)与研究组(70例),对照组患者常规给予抗生素治疗,研究组患者在临床药师的配合指导下给予抗生素治疗,比较两组临床疗效。结果研究组患者抗生素应用时间、平均住院时间均低于对照组,差异均有显著性(t=14.718、28.576,P=0.000、0.000);研究组患者中2例(2.88%)发生脓毒症,对照组患者中10例(14.71%)发生脓毒症,对照组患者脓毒症发生率高于研究组(χ2=6.099,P=0.014),研究组患者中1例(1.43%)发生二次感染,对照组患者中8例(11.76%)发生二次感染,对照组患者二次感染率高于研究组(χ2=6.044,P=0.014)。结论合理使用抗生素有助于患者减少烧伤感染,降低并发症发生率,改善患者预后,提高治疗效果及患者生活质量。

Objective To study the clinical curative effect of bum patients with antibiotic application under the guidance of clinical pharmacists. Method 138 cases bum patients in our hospital were divived into control group （68 cases） and experiment groop （70 cases） according to hospital sequence, control group were griven conventional antibiotic treatment, and the experiment group were given otic dosing under the guidance of clinical pharmacists, and the clinical effect was compared. Result The antibiotics application time and the average hospitalizationl time of experiment group was lower than control group, the difference was statistically significant （t = 14.718, 28.576, P= 0.000, 0. 000）, experiment group 2 cases （2.88%） in sepsis, 10 cases of control group （14.71%）, control group was higher than （x2 = 6.099, P= 0.014）, secondary infection group in 1 case （1.43%） and control group in 8 cases （11.76%）, control group was higher than experiment group （x2 = 6.044, P = 0.014）. Conclusion Rational use of antibiotics help reduce the incidence of bum infection and complications, and improve the effect of treatment and improve prognosis, and promote the patient＇s quality of life.