二甲双胍治疗妊娠期糖尿病疗效和安全性评价

The Clinical Efficacy of Metformin for Gestational Diabetes

目的:观察二甲双胍用于妊娠期糖尿病的临床疗效,评价其安全性。方法:选取2010年12月-2013年12月收治的126例妊娠期糖尿病患者,按照随机数字表法分为对照组和观察组,每组63例。对照组以诺和灵30R控制血糖,早晚餐前皮下注射。观察组以二甲双胍口服,0.5 g,tid,比较两组妊娠结局及不良反应。结果:两组治疗后空腹及餐后2 h血糖均较治疗前显著下降,比较差异均有统计学意义(P<0.05)。至分娩时,观察组体重增加(1.02±0.73)kg,显著低于对照组的(2.13±0.76)kg,两组比较差异有统计学意义(P<0.05)。观察组低血糖发生率、巨大儿比例均显著低于对照组,两组比较差异有统计学意义(P<0.05)。两组患者在尿路感染、子痫前期、剖宫产、羊水过多比例上比较差异均无统计学意义(P>0.05)。结论:二甲双胍治疗妊娠期糖尿病疗效确切,且未增加母婴风险,临床安全。

Objective：To explore the clinical efficacy and evaluate its safety of metformin for gestational diabetes.Method：126 patients were divided into control group and observation group with gestational diabetes according to the patient’s admission in accordance with the order of the random number table randomly,63 cases in each group. The control group was treated with Novolin 30R,and observation group was treated with metformin during pregnancy ends. Result：After treatment,fasting and 2 h postprandial blood glucose decreased significantly than before treatment （P〈0.05）. The difference between the fasting glucose and postprandial 2 h was not statistically significant in the two groups before giving birth （P〉0.05）. When to childbirth,weight gain of pregnant woman in observation group was （1.02±0.73） kg,which was significantly lower than that in the control group’s （2.13±0.76） kg. The incidence of hypoglycemia in the observation group and a huge proportion of children were significantly lower than the control group（P〈0.05）.Conclusion：The metformin has a curative effect on the treatment of gestational diabetes,and not increase the risk of maternal and clinical safety.