胃癌表达Her-2的情况和临床分期的联系

Expression of Her-2 in Stomach Cancer and Its Relationship with Clinical Staging

目的:探讨人表皮生长因子受体2(Her-2)在胃癌中的表达情况以其与胃癌临床分期的联系。方法:选取笔者所在医院就诊的237例胃癌病例,利用免疫组织化学染色法分别检测每个患者手术标本中肿瘤组织与正常胃黏膜的Her-2蛋白的表达情况,进行比较。结果:肿瘤组织Her-2表达的阳性率为26.58%,显著高于正常胃黏膜Her-2表达的阳性率为0%,两组比较差异有统计学意义(P<0.05)。此外,Her-2在胃癌组织中的可疑阳性率31.65%亦显著高于正常胃组织5.06%,两组比较差异有统计学意义(P<0.05)。Ⅳ期患者胃癌标本Her-2蛋白表达的阳性率达64.28%,显著高于Ⅲ、Ⅱ、Ⅰ期,比较差异均有统计学意义(P<0.05);并且随着胃癌分期水平的减低,Her-2阳性率亦随之降低,两者呈正相关。结论:与正常胃黏膜相比,Her-2蛋白在胃癌组织中的表达率显著增高,并且与胃癌分期呈现正相关。

Objective：To explore the expression of Her-2 in stomach cancer and its relation with clinical staging.Method：273 cases of lung cancer in our hospital were selected,then detected the expression of Her-2 in tumour tissues and normal tissues by immunohistochemistry stain and compared the results.Result：The positive rate of Her-2 protein in tumour tissues was 26.58%,which was significantly higher than that in gastric mucosa 0%,the difference was statistically significant（P〈0.05）.Besides,the suspected positive rate of Her-2 in tumour tissues was significantly higher than that in gastric mucosa（P〈0.05）. The statistics showed that the positive Her-2 expression in IV stage was 64.29%,which was significantly higher than stageⅢ,Ⅱ,Ⅰ,and the differences were statistically significant（P〈0.05）,with the reduce of staging level for lung cancer,the positive of Her-2 had reduced,which showed positive correlation between them.Conclusion：The expression level of Her-2 in lung cancer tissues is significantly higher than normal gastric mucosa,and it has positive correlation with cancer staging.