糖脂同调治疗早期糖尿病肾病临床观察

Clinical Observation in Treatment of Diabetic Nephropathy in Early Stage with Combination of Hypoglycemic Active and Regulating Blood-Lipid

目的:观察自拟方治疗早期糖尿病肾病的临床疗效及作用机制。方法:将90例符合糖尿病肾病诊断标准的患者随机分为两组。对照组50例,给予氯沙坦口服治疗。治疗组40例,在对照组治疗基础上给予中药自拟方口服。两组连续治疗2个月后观察治疗前后有效率及肾功能、血脂、尿蛋白、血流变学指标变化。结果:治疗组临床总有效率明显高于对照组(P<0.05)。2组治疗后UAER、TC、TG均有显著改善,且治疗组疗效优于对照组(P<0.05)。治疗组治疗后Scr及血流变学明显改善(P<0.05),对照组改善不明显(P>0.05)。2组治疗后FBG、BUN均无明显改善(P>0.05)。结论:中西医结合治疗早期糖尿病肾病疗效显著,值得临床推广应用。

Objective： To observe the clinical effect and the mechanism on diabetic nephropathy in early stage with decoction made by ourselves. Methods ： 90 cases of diabetic nephropathy in accordance with diagnostic criteria were randomized into 2 groups. The control group （ 40 patients ） used Losartan. The treatment group used traditional Chinese medicine on the base of the control group. The efficacy was observed after 2 months in two groups. Results ： The total effective rate of treatment group was better than that of control group （ P〈0.05 ）. The UAER, TC and TG were obviously improved than those in the control group （P〈0.05）. The blood theology and Scr were obviously improved in the treatment group （P〈0.05）, and no significant improved in the control group （ P〉0.05 ）. There was no significant difference in FBG and BUN both of 2 groups （ P〉0.05 ）. Conclusion ： Combination of traditional Chinese and Western medicine had good cure effect on diabetic nephropathy in early stage and it＇s worthy of clinical use.