VEGF、TNF-α在多囊卵巢综合征中胚胎着床的影响

VEGF and TNF-α of Embryo Implantation in Polycystic Ovary Syndrome

多囊卵巢综合征是一种发病多因性、临床表现多态性的内分泌综合征。不孕症是其并发症之一,即使受孕成功也易发生自然流产或胚胎凋萎,有时即使进行保胎措施也无法改变其流产结局。近年来研究显示,血管内皮生长因子(VEGF)、肿瘤坏死因子(TNF-α)不但与PCOS的发生发展过程关系密切,而且参与卵泡的生长发育及优选、受精率、妊娠率等多个方面。文章就血管内皮生长因子(VEGF)、肿瘤坏死因子(TNF-α)在多囊卵巢综合征中及胚胎着床的相关影响做一下探讨。

Polycystic ovary syndrome is a multiple endocrine syndrome pathogenesis, with clinical manifestations polymorphism. Infertility is one of the complications, even if the pregnancy success also prones to spontaneous abortion or embryo wilting. Sometimes even defend measures can not change the abortion. Recent studies have shown vascular endothelial growth factor （ VEGF ）, tumor necrosis factor alpha （ TNF- α ） not only with the occurrence and development of PCOS are closely related, but also in follicular growth and development and selection, fertilization rate, pregnancy rate etc.. In this paper, vascular endothelial growth factor （ VEGF ） and tumor necrosis factor （ TNF- α ） do something to explore relevant influence in polycystic ovary syndrome and embryo implantation