鸦胆子油注射剂胃癌术后辅助化疗

Effect of Postoperative Application of Brucea Javanica Oil Injection Adjuvant Chemotherapy in Treating Gastric Cancer

目的:研究胃癌术后应用鸦胆子油注射剂辅助化疗的疗效。方法:选择在本院接受手术治疗的108名进展期胃癌患者作为研究对象,随机分为观察组和对照组,对照组给予XELOX辅助化疗(卡培他滨口服+奥沙利铂静脉滴注),观察组给予鸦胆子油注射剂辅助XELOX化疗(卡培他滨口服+奥沙利铂静脉滴注+鸦胆子油注射剂静脉滴注),观察远期预后情况、不良反应例数、总体生活质量以及免疫功能。结果:观察组完全缓解(CR)(8.62%)、有效率(58.62%)、获益率(79.31%)、卡氏行为状态(KPS)评分(84.37±8.21)分、生活质量核心量表(QLQ-C30)评分(81.84±8.34)分、T细胞亚群(CD3+,CD4+,CD8+,CD4+/CD8+)、自然杀伤(NK)细胞(9.31±1.34)%、肿瘤坏死因子α(TNF-α)含量(1.53±0.21)ng·L-1高于对照组,局部复发(10.34%)、远处转移(10.34%)、恶心呕吐(10.34%)、神经毒性(22.41%)、肝功能损害(10.34%)、肾功能损害(12.07%)低于对照组。结论:胃癌术后应用鸦胆子油注射剂辅助化疗能够改善远期预后、减少不良反应,具有积极的治疗价值。

Objective：The purpose of this investigation was to study the effect of postoperative application of Brucea Javanica oil injection adjuvant chemotherapy on treating gastric cancer.Method：One hundred and eight patients with advanced gastric cancer were divided into observation group and control group.The control group was given XELOX adjuvant chemotherapy （oral capecitabine plus oxaliplatin into intravenous drip）,while the observation group was given auxiliary Brucea Javanica oil injection besides XELOX chemotherapy （oral capecitabine plus oxaliplatin into intravenous drip ＋ Brucea Javanica oil injection intravenous drip）.The long-term prognosis,adverse reactions,overall life quality and immune function were compared.Result：Complete response （CR） （8.62％）,efficiency （58.62％）,benefit rate （79.31％）,karnofsky （KPS） score （84.37 ±8.21）,QLQ-C30score （81.84 ±8.34）,CD3＋,CD4＋,CD8＋,CD4＋/CD8＋,natural killer （NK） （9.31 ±1.34）％,tumor necrosis factor （TNF-α） （1.53 ±0.21） ng ·L-1 of observation group were higher than control group,while local recurrence （10.34％）,distant metastasis （10.34％）,nausea and vomiting （10.34％）,neurotoxicity （22.41％）,liver function damage （10.34％）,renal function damage （12.07％） were lower than control group.Conclusion：Postoperative application of Brucea Javanica oil injection adjuvant chemotherapy has positive therapeutic value for it can improve the prognosis and reduce the adverse reaction.