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黄山药化学成分、药理作用及临床应用研究进展 被引量:6

Advances on Chemical Constituents,Pharmacological Effects and Clinical Applications of Dioscorea Panthaicae Rhizoma
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摘要 黄山药为我国特有的薯蓣科薯蓣属植物,是国家级(五类)新药地奥心血康的主要药源,该药于2012年获准荷兰上市。本文通过查阅近15年国内外有关黄山药的研究报道,对黄山药化学成分、药理作用以及临床应用进行了综述。对黄山药化学成分研究以甾体皂苷类成分为主,具有治疗心肌缺血、降血脂和抗肿瘤等作用,且临床上对于心肌缺血的应用得到了广泛关注。目前分离得到的甾体皂苷化合物数目还偏少,且药理活性的研究大都集中在薯蓣皂苷上,据此,对黄山药其余甾体皂苷以及其他种类化学成分的发掘和药理活性研究的深度和广度相对匮乏。所以,对其化学成分及药理活性还有待进一步深入研究,以期更好地开发利用。 Objective:Dioscorea Panthaica Rhizoma is the main raw material of Di'ao Xinxuekang,which was approved to sell as drug in Holland in 2012.In this review,researches of the chemical components of D.panthaica,their pharmacological actions and clinical applications were summarized based on the domestic and abroad literatures in past 15 years.The researches of the chemical constituents in D.panthaica focused on steroid saponins,which had curing myocardial ischemia,hypolipidemic and antitumous effecst,and its treatment of myocardial ischemia had drawn widely attention of medical field.Compounds isolated from this herb were less,and only dioscin underwent further researches of pharmacological activities.While the discoveries of the other steroidal saponins and their chemical constituents as well as their pharmacological actions were very scarce.Thereby further research of D.panthaica is worthwhile to fulfill the use of plant resources.
出处 《中国实验方剂学杂志》 CAS 北大核心 2014年第18期235-242,共8页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家"重大新药创制"科技重大专项(2011ZX09401-028 2011-2013)
关键词 黄山药 化学成分 药理作用 临床应用 Dioscorea Panthaica Rhizoma chemical components pharmacological actions clinical applications
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