摘要
目的 探讨静息心率(RHR)与臂踝脉搏波传导速度(baPWV)的关系.方法 采用横断面研究设计,在2006至2007年参加健康体检的101 510例开滦集团职工中,以分层随机抽样方法抽取5 852例作为研究对象,进行统一问卷调查、血液生化及baPWV检查.符合入选标准的研究对象(年龄≥40岁、既往无卒中、短暂性脑缺血发作、心肌梗死者)共5 440例,将其中资料完整的5 153例纳入统计分析.依据2010至201 1年健康体检时RHR的四分位数,将研究对象分为第一分位组(RHR< 63次/min,n=1 405)、第二分位组(63次/min≤RHR< 69次/min,n=1 176)、第三分位组(69次/min≤RHR< 76次/min,n=1 322)、第四分位组(RHR≥76次/min,n=1 250).采用多因素logistic回归分析RHR与baPWV的关系.结果 (1)研究对象的年龄为(55.1±11.8)岁;男性3 110例,女性2 043例;baPWV为(1 586±400) cm/s;baPWV≥1 400 cm/s的检出率为61.8%(3 185/5 153).(2)第一、二、三、四分位组的baPWV分别为(1 511±338) cm/s、(1 533±329) cm/s、(1 574±368) cm/s、(1 734±462) cm/s;baPWV≥1 400 cm/s的检出率分别为54.7% (769/1 405)、56.0% (658/1 176)、63.1% (834/1 322)、74.3% (929/1 150).(3)多因素logistic回归分析显示:校正年龄、性别、收缩压、体质指数、空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、高敏C反应蛋白、是否服用降压药、吸烟和体育锻炼后,与第一分位组比较,第二、三和四分位组baPWV≥1 400 cm/s的检出率均增加,OR值分别为1.37(95% CI:1.11 ~1.69)、1.96(95% CI:1.59 ~2.41)和2.60(95% CI:2.07 ~3.25).结论 RHR加快与baPWV增加独立相关.
Objective To investigate the relationship between resting heart rate (RHR) and brachial-ankle pulse wave velocity (baPWV) in healthy Chinese population.Methods This was a retrospective cohort study,and a total of 5 852 participants were selected with stratified random sampling from the 101 510 workers of Tangshan Kailuan company who received the health examination during 2010-2011 including epidemiological investigation,biochemical indicators measurement and baPWV measurement.A total of 5 440 participants met the inclusion criteria (aged 40 years or older,without stroke,transient ischemic attack and myocardial infarction) and 5 153 participants (3 110 males,mean age (55.1 ± 11.8) years old) with integral data were finally recruited into the final analysis.The observation population was divided into four groups according to RHR collected during health examinations:quartile 1 (RHR≤63 beats/min,n =1 405) ; quartile 2 (63 beats/min < RHR≤69 beats/min,n =1 176) ; quartile 3 (69 beats/min < RHR ≤76 beats/min,n =1 322) ; quartile 4 (RHR > 76 beats/min,n =1 250).Multivariate logistic regression analysis was used to analyze the relationship between RHR and baPWV.Results (1) The mean baPWV was (1 586 ± 400) cm/s,and the detection rates of baPWV ≥1 400 cm/s was 61.8% (3 185/5 153).(2)The baPWV of quartile 1,2,3 and 4 were (1 511 ±338) cm/s,(1 533 ±329) cm/s,(1 574 ±368) cm/s and (1 734 ±462) cm/s,respectively,and the detection rates of baPWV≥ 1 400 cm/s were 54.7% (769/1 405),56.0% (658/1 176),63.1% (834/1 322) and 74.3%(929/1 150),respectively.(3) Multiple logistic regression analysis showed that the detection rates of baPWV were significantly higher in quartile 2,3 and 4 compared to quartile 1,and the OR values were 1.37 (95 % CI:1.11-1.69),1.96 (95 % CI:1.59-2.41) and 2.60 (95 % CI:2.07-3.25),respectively,after adjusting for age,gender and systolic blood pressure,body mass index,fasting blood glucose,triglyceride,total cholesterol,high density lipoprotein cholesterol,hs-CRP,antihypertensive agents,smoking and exercise status.Conclusion RHR is positively associated with baPWV in healthy Chinese population.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2014年第8期686-692,共7页
Chinese Journal of Cardiology
关键词
心率
臂踝脉搏波传导速度
危险因素
Heart rate
Brachial-ankle pulse wave velocity
Risk factors