期刊文献+

破译肠道代谢信息 推动治疗改革创新——第74届美国糖尿病学会年会Banting奖演讲解读

原文传递
导出
摘要 为纪念胰岛素之父Frederik Banting而设的Banting科学成就奖(以下简称Banting奖),是美国糖尿病学会(ADA)的最高科学奖项.今年摘取第74届ADA科学年会Banting奖桂冠的Daniel J Drucker博士,是加拿大多伦多大学Banting和Best糖尿病中心医学教授、西奈山医院Lunenfeld Tanenbaum研究所资深科学家,继2012年在柏林欧州糖尿病学会(EASD)获得第44届Claude Bernard奖之后,今年是他再次因阐肠道激素作用的基本原理而获奖.6月15日上午,美国旧金山市Moscone国际会议中心,Drucker教授以"破译肠道代谢信息,推动治疗改革创新"为题作获奖致辞.
作者 施亚雄
出处 《中华糖尿病杂志》 CAS CSCD 2014年第8期575-578,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
  • 相关文献

参考文献22

  • 1Drucker D J, Philippe J, Mojsov S, et al. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line[J]. Proe Natl Aead Sei U S A,1987, 84:3434-3438.
  • 2Eng J, Kleinman WA, Singh L, et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas[J]. J Biol Chem, 1992,267:7402-7405.
  • 3Chen YE, Drucker DJ. Tissue-specific expression of unique mRNAs that encode proglueagon-defived peptides or exendin 4 in the lizard[J]. J Biol Chem, 1997,272:4108-4115.
  • 4Scrocchi LA, Brown TJ, MaClusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon- like peptide 1 receptor gene[J]. Nat Med, 1996,2:1254-1258.
  • 5Li Y, Hansotia T, Yusta B, et al. Glucagon-like peptide- 1 receptor signaling modulates 13 cell apoptosis[J]. J Biol Chem, 2003,278:471-478.
  • 6Yusta B, Baggio LL, Estall JL, et al. GLP- 1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress[J]. Cell Metab,2006,4:391-406.
  • 7Baggio LL, Huang Q, Brown TJ, et al. A recombinant human glucagon- like peptide (GLP) - 1- albumin protein (albugon) mimics peptidergic activation of GLP- 1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis[J]. Diabetes,201M,53:2492-2500.
  • 8Baggio LL, Huang Q, Cao X, et al. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis[J]. Gastroenterology, 2008,134:1137-1147.
  • 9Lamont B J, Li Y, Kwan E, et al. Pancreatic GLP- 1 receptor activation is sufficient for incretin control of glucose metabolism in mice[J]. J Clin Invest,2012,122:388-402.
  • 10Rasmussen HB, Branner S, Wiberg FC, et al. Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog[J]. Nat Struct Biol,2003,10:19-25.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部