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地特胰岛素在糖尿病治疗中的应用 被引量：4

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摘要 糖尿病治疗的关键是尽可能将血糖控制在正常范围,并避免低血糖的发生.由于2型糖尿病进行性发展的特点,患者或早或晚都将进入胰岛素治疗.基础胰岛素每天一次是常用的胰岛素起始治疗方案之一.传统的中效人胰岛素由于其血药浓度波动的特点可能有更多的低血糖风险,且作用时间不足24 h,目前已逐渐被作用更平缓、时间更长的胰岛素类似物所取代.地特胰岛素是常用的长效胰岛素类似物之一.该胰岛素低血糖风险小、减少体重增加,且适用人群广,被广泛应用于基础胰岛素治疗.本文就地特胰岛素的上述特点在临床研究中的证据作一综述.
作者 石勇铨
机构地区 第二军医大学长征医院内分泌科
出处 《中华糖尿病杂志》 CAS CSCD 2014年第8期624-626,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 地特胰岛素 2型糖尿病 治疗方案 应用 长效胰岛素类似物 胰岛素低血糖 胰岛素治疗 中效人胰岛素
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献22

  • 1Home P, Kurtzhals P. Insulin detemir: from concept to clinical experience[J]. Expert Opin Pharmacother,2006,7:325-343.
  • 2Bartley PC, Bogoev M, Larsen J, et al. Long- term efficacy and safety of insulin detemir compared to neutral protamine hagedorn insulin in patients with type 1 diabetes using a treat- to-target basal-bolus regimen with insulin aspart at meals: a 2- year, randomized, controlled trial[J]. Diabet Med,2008,25:442- 449.
  • 3Philis-Tsimikas A, Charpentier G, Clauson P, et al. Comparison of onee-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes[J]. Clin Tber,2006,28:1569 - 1581.
  • 4Frier BM, Russell-Jones D, Heise T. A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review[J]. Diabetes Obes Metab,2013,15:978-986.
  • 5Yale JF, Damei T, Kaiser M, et al. Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study [J]. Diabetol Metab Syndr,2013,5:56.
  • 6Zilov A, E1 NN, Shah S, et al. Insulin detemir in the management of type 2 diabetes in non-western countries: safety and effectiveness data from the A ( l ) chieve observational study [J]. Diabetes Res Clin Pract,2013,101:317-325.
  • 7Haukka J, Hoti F, Erasta P, et al. Evaluation of the incidence and risk of hypoglycemie coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study[J]. Pharmacoepidemiol Drug Saf,2013,22:1326- 1335.
  • 8Wei M, Gaskill SP, Haffner SM, et al. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study[J]. Diabetes Care, 1998,21:1167-1172.
  • 9van Golen LW, Ijzerman RG, Huisman MC, et al. Cerebral blood flow and glucose metabolism in appetite-related brain regions in type 1 diabetic patients after treatment with insulin detemir and NPH insulin: a randomized controlled crossover trial]J]. Diabetes Care,2013,36:4050-4056.
  • 10Hendriksen KV, Jensen T, Oturai P, et al. Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients[J]. Diabetologia, 2012,55:46-50.

二级参考文献5

  • 1American Diabetes Association. Standards of Medical Care in Diabetes-2011[J].Diabetes Care,2011.S11-S61.
  • 2Jovanovic L. The role of continuous glucose monitoriog in gestational diabetes mellitus[J].Diabetes Technol Therap,2000,(Suppl 1):S67-S71.
  • 3Catalano PM,Tyzbir ED,Wolfe RR. Carbohydrate metaholism during pregnancy in control subjects and women with gestational diabetes[J].American Journal of Physiology,1993.E60-E67.
  • 4Kuroda A,Kaneto H,Yasuda T. Basal insulin requirement is ～ 30% of the total daily insulin dose in type 1 diabetic patients who use the insulin pump[J].Diabetes Care,2011.1089-1090.
  • 5贾伟平.动态血糖监测技术：临床应用新拓展[J].中华糖尿病杂志,2011,3(3):193-195. 被引量：10

共引文献10

同被引文献30

  • 1UK. prospective diabetes study 16 years therapy of type II dia- betes:a progressive disease. UK Prospective Diabetes Study Group[J]. Diabetes, 1995,44 ( 11 ) : 1249-1258.
  • 2Nathan DM, Buse JB, Davidson MB, et al. Management of hy- perglycemia in type2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the EuropeanAs- sociation for the Study of Diabetes [ J ]. Diabetes Care, 2006, 29 : 1963-1972.
  • 3Brod M, Kongs JH, Lessard S, et al. Psychological insulin re- sistance:patienl beliefs and implications for diabetes manage- ment[ J]. Qual Life Res,2009,18:23-32.
  • 4Papa G, Degano C, Iurato P, et al. Efficacy and safety of insu- lin detemir VS glargine as add-on to metformin and repaglinide in patients with type 2 diabetes and inadequate glycaemic con- trol with oral anIihyperglycaemic agents [ J ]. Diabetol Metab, 2011,31:192-198.
  • 5中华医学会糖尿病学分会护理及糖尿病教育学组中国糖尿病护理及教育指南[R].2009:13-17.
  • 6Whittingham JL, Havelund S, Jonassen I. Crystal structure of a prolonged-actinginsulin with albumin-binding properties [ J ]. Biochemistry, 1997,36 : 2826 -2831.
  • 7Philips-Tsimikas A. An update on the use of insulin detemir, with a focus on type 2 diabetes( drug evaluation update) [ J]. Expert Opin Pharmacother, 2008,9 : 2181-2195.
  • 8沈洁.地特胰岛素减少体重增加的可能机制与临床应用[J].中国糖尿病杂志,2010,18(3):238-240. 被引量：41
  • 9田慧.2型糖尿病的胰岛素治疗[J].健康指南（中老年）,2011(4):10-12. 被引量：1
  • 10王晓洲,栾晓军,陈劲松,陈小雨,胡利东,梁明,吴仰帆.地特胰岛素联合二甲双胍和瑞格列奈治疗新诊断2型糖尿病患者的疗效及安全性观察[J].中国医药指南,2013,11(36):460-461. 被引量：7

二级引证文献20

中华糖尿病杂志
2014年 第8期

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