浙江省慈溪市企事业单位人员非酒精性脂肪肝患病率及危险因素分析

Prevalence of non-alcoholic fatty liver and risk factors in office workers in Cixi,Zhejiang

目的了解浙江省慈溪市企事业单位人员非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患病率及危险因素,为NAFLD的防治提供参考。方法对2012年8-12月在慈溪市人民医院体检中心进行健康体检的1256名企事业单位工作人员,采取体格检查、血生化检查、B超检查和问卷调查的方法,进行脂肪肝患病率及危险因素的调查。单因素分析各变量赋值后用Chi-square检验,多因素分析采用多元logistic回归分析。结果 1256名入选人员共检出NAFLD 251例,患病率为20.94%。单因素分析显示,NAFLD组在性别(χ2=54.895)、年龄(χ2=69.068)、腰围(χ2=242.093)、腰臀比(χ2=11.973)、体质指数(χ2=161.004)、高尿酸血症(χ2=64.468)、每周锻炼次数(χ2=15.370)、常在外就餐(χ2=4.322)、常吃夜宵(χ2=39.527)、出行方式(χ2=8.454)、谷丙转氨酶(ALT)(χ2=39.998)、甘油三脂(TG)(χ2=100.860)、高密度脂蛋白(HDL-C)(χ2=99.393)、糖尿病发生率(χ2=5.129)方面与非NAFLD组比较,差异均有统计学意义(P<0.05);在高血压发生率(χ2=3.559)、谷草转氨酶(χ2=3.693)、胆固醇(TC)(χ2=0.129)、低密度脂蛋白(LDL-C)(χ2=1.407)方面,两组比较差异无统计学意义(P>0.05)。logistic回归分析表明:性别、年龄、腰围、体质指数、高尿酸血症、每周锻炼次数、常吃夜宵、ALT、TG、HDL-C与NAFLD的发生密切相关。结论慈溪市企事业单位人员NAFLD患病率高,其中年龄、腰围、体质指数、高尿酸血症、常吃夜宵、高ALT、高TG是危险因素;而性别(女性)、每周锻炼次数、高HDL-C是保护因素。

Objective To understand the prevalence of non-alcoholic fatty liver and related risk factors in office workers in Cixi,Zhejiang province. Methods A total of 1256 office workers in Cixi received health examination,including biochemical detection and B-ultrasound detection,in our hospital from August 2012 to December 2012,and questionnaire survey were conducted among them. The risk factors of non-alcoholic fatty liver were analyzed by Chi-square test and logistic regression analysis. Results The prevalence of non-alcoholic fatty liver was 20. 94%（251 /1256）. There was significant differences in gender（χ2= 54. 895）,age（χ2= 69. 068）,waist circumference（WC）（χ2= 242. 093）,waist-tohip ratio（WHR）（χ2= 11. 973）,body mass index（BMI）（χ2= 161. 004）,hyperuricacidemia prevalence（χ2= 64. 468）,time of weekly exercise（χ2= 15. 370）,eating out（χ2= 4. 322）,night eating（χ2= 39. 527）,way to travel（χ2= 8. 454）,alanine aminotransferase（ALT） level（χ2= 39. 998）,triglyeride（TG） level（χ2= 100. 860）,high-density lipoproteinscholesterol（HDL-C） level（ χ2= 99. 393）,diabetes prevalence（ χ2= 5. 129） between case group and control group（P 0.05）; but there was no statistical differences in hypertension prevalence（χ2= 3. 559）,aspartate aminotransferase（AST） level（χ2= 3. 693）,cholesterol level（χ2= 0. 129）,low density lipoprotein-cholesterol level（χ2= 1. 407） between the 2 groups（P 0. 05）. Logistic regression analysis indicated that gender,age,WC,BMI,hyperuricacidemia,time of weekly exercise,night eating,ALT level,TG level and HDL-C level were significant independent factors of non-alcoholic fatty liver. Conclusion The prevalence of non-alcoholic fatty liver was relatively higher in office workers in Cixi. The risk factors included age,WC,BMI,hyperuricacidemia,night eating,ALT level and TG. level The protective factors included gender（female）,time of weekly exercise,HDL-C level.