摘要
目的了解浙江省慈溪市企事业单位人员非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患病率及危险因素,为NAFLD的防治提供参考。方法对2012年8-12月在慈溪市人民医院体检中心进行健康体检的1256名企事业单位工作人员,采取体格检查、血生化检查、B超检查和问卷调查的方法,进行脂肪肝患病率及危险因素的调查。单因素分析各变量赋值后用Chi-square检验,多因素分析采用多元logistic回归分析。结果 1256名入选人员共检出NAFLD 251例,患病率为20.94%。单因素分析显示,NAFLD组在性别(χ2=54.895)、年龄(χ2=69.068)、腰围(χ2=242.093)、腰臀比(χ2=11.973)、体质指数(χ2=161.004)、高尿酸血症(χ2=64.468)、每周锻炼次数(χ2=15.370)、常在外就餐(χ2=4.322)、常吃夜宵(χ2=39.527)、出行方式(χ2=8.454)、谷丙转氨酶(ALT)(χ2=39.998)、甘油三脂(TG)(χ2=100.860)、高密度脂蛋白(HDL-C)(χ2=99.393)、糖尿病发生率(χ2=5.129)方面与非NAFLD组比较,差异均有统计学意义(P<0.05);在高血压发生率(χ2=3.559)、谷草转氨酶(χ2=3.693)、胆固醇(TC)(χ2=0.129)、低密度脂蛋白(LDL-C)(χ2=1.407)方面,两组比较差异无统计学意义(P>0.05)。logistic回归分析表明:性别、年龄、腰围、体质指数、高尿酸血症、每周锻炼次数、常吃夜宵、ALT、TG、HDL-C与NAFLD的发生密切相关。结论慈溪市企事业单位人员NAFLD患病率高,其中年龄、腰围、体质指数、高尿酸血症、常吃夜宵、高ALT、高TG是危险因素;而性别(女性)、每周锻炼次数、高HDL-C是保护因素。
Objective To understand the prevalence of non-alcoholic fatty liver and related risk factors in office workers in Cixi,Zhejiang province. Methods A total of 1256 office workers in Cixi received health examination,including biochemical detection and B-ultrasound detection,in our hospital from August 2012 to December 2012,and questionnaire survey were conducted among them. The risk factors of non-alcoholic fatty liver were analyzed by Chi-square test and logistic regression analysis. Results The prevalence of non-alcoholic fatty liver was 20. 94%(251 /1256). There was significant differences in gender(χ2= 54. 895),age(χ2= 69. 068),waist circumference(WC)(χ2= 242. 093),waist-tohip ratio(WHR)(χ2= 11. 973),body mass index(BMI)(χ2= 161. 004),hyperuricacidemia prevalence(χ2= 64. 468),time of weekly exercise(χ2= 15. 370),eating out(χ2= 4. 322),night eating(χ2= 39. 527),way to travel(χ2= 8. 454),alanine aminotransferase(ALT) level(χ2= 39. 998),triglyeride(TG) level(χ2= 100. 860),high-density lipoproteinscholesterol(HDL-C) level( χ2= 99. 393),diabetes prevalence( χ2= 5. 129) between case group and control group(P 0.05); but there was no statistical differences in hypertension prevalence(χ2= 3. 559),aspartate aminotransferase(AST) level(χ2= 3. 693),cholesterol level(χ2= 0. 129),low density lipoprotein-cholesterol level(χ2= 1. 407) between the 2 groups(P 0. 05). Logistic regression analysis indicated that gender,age,WC,BMI,hyperuricacidemia,time of weekly exercise,night eating,ALT level,TG level and HDL-C level were significant independent factors of non-alcoholic fatty liver. Conclusion The prevalence of non-alcoholic fatty liver was relatively higher in office workers in Cixi. The risk factors included age,WC,BMI,hyperuricacidemia,night eating,ALT level and TG. level The protective factors included gender(female),time of weekly exercise,HDL-C level.
出处
《疾病监测》
CAS
2014年第8期660-664,共5页
Disease Surveillance
基金
浙江省中医药科学研究基金课题项目(No.2011ZA0990)~~