摘要
[目的]研究旋光性除草剂萘氧丙草胺的合成方法。[方法]以手性L-乳酸甲酯为初始原料,经磺化,再与琢-萘酚缩合,再经碱解、酸化、酰化,最后和二乙胺定向合成得具有旋光活性的左旋萘氧丙草胺。[结果]在优化的反应条件下,反应总收率89.3%(以琢-萘酚计),光学纯度98%;产物结构经1H NMR确证。[结论]该反应条件温和,收率高,可以作为R-左旋萘氧丙草胺的一种有效合成方法在工业上进行推广应用。
[Aims] This study aims to screen out the synthetic method of optically active herbicide naphthoxyacetic. [Methods] With L-methyl lactate as the starting material, sulfonated, and then via c{-naphthol condensation, after alkaline hydrolysis, acidification, acylation, and diethylamine finally directed synthesis of optically active R (-) napropamide. [Results] Under the optimal reaction conditions, the total yield of R(-)napropamide was 89.3%(based on α-naphthol), and the optical purity was 98%. The structure of product was confirmed by ^1H NMR. [Conclusions] This method can be used as an effective route of R (-)napropamide on industrial scale for the advantages of mild reaction condition and high yield.
出处
《农药》
CAS
CSCD
北大核心
2014年第9期636-637,共2页
Agrochemicals
关键词
除草剂
旋光性
萘氧丙草胺
合成
herbicide
optical activity
R(-)napropamide
synthesis