温热疗法与10%聚维酮碘联合激光治疗复发性尖锐湿疣

Combination of thermotherapy with 10% povidone iodine and laser in treatment of recurrent condyloma acuminatum

目的:探讨温热疗法与10%聚维酮碘联合激光治疗复发性尖锐湿疣的有效性及安全性。方法:将60例复发性尖锐湿疣患者随机分为A、B组,每组30例。A组应用温热疗法与10%聚维酮碘联合激光治疗;B组应用激光治疗;小于1 cm疣体的复发性尖锐湿疣患者30例作为C组,应用光动力治疗。每组观察6个月然后判定疗效。结果:A组治愈27例,复发3例;B组治愈19例,复发11例;C组治愈26例,复发4例;A组疗效优于B组(χ2=5.963,P=0.015);而A组与C组的疗效比较差异无统计学意义(χ2=0.162,P=0.688)。A组治疗期间出现可耐受不良反应。结论:温热疗法与10%聚维酮碘联合激光治疗复发性尖锐湿疣有效而安全,优于单纯激光治疗,与光动力治疗疗效相当。

Objective：To investigate the efficacy and safety of the combination of thermotherapy with 10% povidone iodine and laser in treatment of recurrent condyloma acuminatum.Methods：Sixty patients with recurrent condyloma acuminatum were randomly divided into A and B groups（n=30）.Group A,combination of thermotherapy with 10% povidone iodine and laser; Group B,laser treatment alone.Patients who had recurrent condyloma acuminatum with wart body diameter less than 1 cm were assigned into Group C,subjected to photodynamic therapy.Each group was observed for 6 months to determine efficacy.Results：In Group A,27 patients were cured and 3 recurred.In Group B,19 patients were cured and 11 recurred.In Group C,26 patients were cured and 4 recurred.The efficacy in Group A was better than that in Group B（χ2=5.963,P=0.015）,but there was no significant difference between A and C group（χ2=0.162,P=0.688）.Some side effects appeared in patients in Group A during the treatment but all patients were able to tolerate them.Conclusion：The combination thermotherapy with 10% povidone iodine and laser in treatment of recurrent condyloma is effective and safe,which shows similar therapeutic effect to photodynamic treatment.