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微小RNA在糖尿病肾病发病机制及治疗中的研究进展 被引量：6

Research progress of miRNA in the pathogenesis and the treatment of diabetic nephropathy
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摘要 微小RNA(microRNAs,miRNA)可在转录后水平调控基因表达。最新研究表明miRNA与糖尿病肾病肾纤维化、足细胞损伤、系膜增生、微血管病变等密切相关,在糖尿病肾病的发病中可能起着必不可少的作用。深入研究miRNA可能为糖尿病肾病的诊断和治疗带来全新的方法。 MicroRNAs （miRNAs） can regulate the expression ofgene in the post transcription. Recently, studies demonstrate that miRNA is closely related to renal fibrosis, podocyte injury, mesangial proliferation, and vascular lesions in diabetic nephropathy. MiRNA may play an essential role in the pathogenesis of diabetic nephropathy. Further study on miRNA may bring new methods for the diagnosis and treatment of diabetic nephropathy.
作者 郑林峰 唐文彬 陈立平
机构地区 中南大学湘雅医院肾内科
出处 《临床与病理杂志》 CAS 2014年第4期435-439,共5页 Journal of Clinical and Pathological Research
基金 国家自然科学基金青年基金(81100515)~~
关键词 MICRORNA 糖尿病肾病 发病机制 治疗进展 microRNA diabetic nephropathy pathogenesis treatment progress
分类号 R587.2 [医药卫生—内分泌]
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参考文献8

  • 1Richard J. MacIsaac,Elif Ekinci,George Jerums.Markers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease[J].American Journal of Kidney Diseases.2013
  • 2Merle Hanke,Kai Hoefig,Hartmut Merz,Alfred C. Feller,Ingo Kausch,Dieter Jocham,Jens M. Warnecke,Georg Sczakiel.A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer[J].Urologic Oncology: Seminars and Original Investigations.2010(6)
  • 3Charles H.Lawrie,ShiraGal,Heather M.Dunlop,BeenaPushkaran,Amanda P.Liggins,KarenPulford,Alison H.Banham,FrancescoPezzella,JacquelineBoultwood,James S.Wainscoat,Christian S. R.Hatton,Adrian L.Harris.Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma[J].British Journal of Haematology.2008(5)
  • 4Dwi Setyowati Karolina,E.M. Wintour,John Bertram,Kandiah Jeyaseelan.Riboregulators in kidney development and function[J].Biochimie.2009(3)
  • 5Shinji Hagiwara,Aaron McClelland,Phillip Kantharidis,Tomohito Gohda.MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway[J].Journal of Diabetes Research.2013
  • 6David P. Bartel.MicroRNAs: Target Recognition and Regulatory Functions[J].Cell.2009(2)
  • 7Brandi N. Davis,Aaron C. Hilyard,Peter H. Nguyen,Giorgio Lagna,Akiko Hata.Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha[J].Molecular Cell.2010(3)
  • 8Xi Chen,Yi Ba,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jig ang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang.Characterization of microRNAs in serum： a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Research,2008,18(10):997-1006. 被引量：982

二级参考文献20

  • 1Duffy MJ. Clinical uses of tumor markers: a critical review. Crit Rev Clin Lab Sci 2001; 38:225-262.
  • 2Thomas CM, Sweep CG. Serum tumor markers: past, state of the art, and future, lnt J Biol Markers 2001; 16:73-86.
  • 3Duffy MJ. Role of tumor markers in patients with solid cancers: a critical review. Eur J lntern Med 2007; 18:175-184.
  • 4Roulston JE. Limitations of tumour markers in screening. Br J Surg 1990; 77:961-962.
  • 5Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.
  • 6Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6:857-866.
  • 7Chen C, Ridzon DA, Broomer A J, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33:e179.
  • 8Tang F, Hajkova P, Barton SC, Lao K, Surani MA. MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res 2006; 34:e9.
  • 9Hafner M, Landgraf P, Ludwig J, et al. Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods 2008; 44:3-12.
  • 10Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103:2257-2261.

共引文献981

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临床与病理杂志
2014年 第4期

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