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Irisin与胰岛素抵抗相关疾病

Association between irisin and insulin resistance-related diseases
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摘要 Irisin是由包含Ⅲ型纤连蛋白重复序列基因家族中的一员——含III型纤连蛋白域蛋白5(fibronectin type Ⅲ domain containing protein 5,FNDC5)裂解、释放而产生。肌肉组织是irisin产生的主要组织,而皮下和内脏脂肪组织也可分泌irisin。Irisin既是一种肌细胞因子,亦是一种脂肪因子,是连接肌肉、脂肪与其他组织的重要信使,并在机体能量代谢平衡方面发挥着重要作用,有可能成为治疗肥胖、2型糖尿病及代谢综合征新的潜在靶点。 Irisin is a cleaved fragment from fibronectin Type Ⅲ domain containing protein 5 （FNDCS）, which is a member of fibronectin Type Ⅲ repeat containing gene family. Muscle is the major source of FNDG5. However, it is also expressed and secreted by subcutaneous and visceral adipose tissue. Therefore, FNDGS is not only a myokine but also an adipokine. It might be an important messenger between muscle and other tissues and plays an important role in the metabolism of the body＇s energy balance. It is a novel potential target in the treatment of obesity, Type 2 diabetes mellitus and metabolic syndrome.
作者 谢心苗 于雪梅
机构地区 南方医科大学第三临床医学院内分泌代谢科 南方医科大学上海市奉贤区中心医院内分泌代谢科
出处 《临床与病理杂志》 CAS 2014年第4期455-460,共6页 Journal of Clinical and Pathological Research
基金 上海市医学重点专科建设计划(ZK2012B16)~~
关键词 irisin 胰岛素抵抗 肥胖 2型糖尿病 代谢综合征 irisin insulin resistance obesity Type 2 diabetes mellitus metabolic syndrome
分类号 R587.1 [医药卫生—内分泌] R589 [医药卫生—内分泌]
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参考文献10

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临床与病理杂志
2014年 第4期

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