不同依赖时间对甲基苯丙胺依赖者空间认知功能的影响

The different durations of methamphetamine abuse influenced abusers＇ spatial processing function

目的 探讨不同依赖时间对甲基苯丙胺依赖者空间认知功能造成的影响.方法 采用心理旋转任务对甲基苯丙胺依赖者（35例）和正常被试者（30例）的空间认知能力进行研究,根据依赖时间长短将甲基苯丙胺依赖者分为2组（依赖1年组16人,依赖3年组19人）,要求被试者判断不同旋转角度手/足图片中肢体的左右,并记录3组被试者的反应时与正确率.结果 同正常被试组相比,2组甲基苯丙胺依赖者的反应速度与正确率均下降,依赖1年组在心理旋转角度为0°[（1469±318） ms]和180°[（1718±412）ms]的反应时、依赖3年组在心理旋转角度为0°[（1466±243） ms]、60°[（1497±294） ms]和180°[（1708±288） ms]的反应时明显延长,差异有统计学意义（P＜0.05）.结论 长期依赖甲基苯丙胺会损害依赖者的空间认知功能.

Objective To investigate the effects of different durations of methamphetamine abuse on spatial cognitive processing.Methods The mental rotation task was used to evaluate the spatial processing function of 35 methamphetamine abusers and 30 healthy subjects.The methamphetamine abusers are divided into 2 groups according to their abuse durations,group 1 contains 16 abusers with an average duration of 1 year and group 2 contains 19 abusers with an average duration of 3 years.Participants were asked to judge the right hand/food or the left hand/food of the experimental stimuli at difference angles.The reaction time （RT） and the accurate rate （AR） of the mental rotation task were recorded.Results Compared with the control group,RT of group 1 methamphetamine abusers was longer at the angle of 0°（（1469±318）ms） and 180°（（1718±412）ms） （P＜0.05）,RT of group 2 was longer at the angle of 0°（（1466±243） ms）,60°（（1497±294） ms） and 180°（（1708±288） ms） （P ＜0.05）.And the AR of methamphetamine abusers was higher at every angle （P＜0.05）.Conclusion Long-term dependence on methamphetmine can damage the abuser＇s spatial processing function.