免疫组织化学临床病理应用与肿瘤分子意义

Immunohistochemical clinical pathological application and tumor molecular significance

医学科技日新月异,20世纪70年代随着单克隆抗体技术的发展,在病理学上开展了免疫组织化学(IHC),其把人们从传统病理组织学(形态学)推向蛋白质水平(抗原、抗体的定性和定位),在现代病理诊断中的应用日益广泛,尤其在肿瘤诊断与鉴别中起着非常重要的作用,对于诊断肿瘤、肿瘤分类、判断预后产生了巨大的影响,扩展了对各种疾病及肿瘤形成过程的认识,提高了病理诊断与研究水平。近来肿瘤的分子病理诊断及靶向治疗的意义成为研究热点。

Medical technology is changing rapidly,in the 1970s with the development of monoclonal antibody technol-ogy,immunohistochemistry （IHC） is developed in pathology,IHC brings people from the traditional pathological histolo-gy （morphology） into protein levels （qualitative and positioning of antigen and antibody） and it is widely applied in-creasingly in modern pathological diagnosis,and plays a very important role in tumor diagnosis and differential and has a great influence on diagnosis of tumor,tumor classification,prognosis estimation,and expandes people’s understanding of the various diseases and tumor formation,improve the level of the pathological diagnosis and research.Recent molec-ular pathological diagnosis of tumor and the significance of targeted therapy becoms a hot research topic.